TRIM10 binds to IFN‐α/β receptor 1 to negatively regulate type I IFN signal transduction
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202049073
Abstract: The type I interferon (IFN‐I) system is important for antiviral and anticancer immunity. Prolonged activation of IFN/JAK/STAT signaling is closely associated with autoimmune diseases. TRIM10 dysfunction may be associated closely with certain autoimmune disorders. Here,… read more here.
Keywords: stat signaling; jak stat; signaling pathway; ifn jak ... See more keywords
Umbelliferone attenuates diabetic cardiomyopathy by suppression of JAK/STAT signaling pathway through amelioration of oxidative stress and inflammation in rats
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23296
Abstract: Umbelliferone (UMB), 7‐hydroxycoumarin, is a naturally occurring coumarin derivative that has a plethora of biological and therapeutic activities. The focus of this research was to elucidate the curative effects of two different doses of UMB… read more here.
Keywords: stat signaling; signaling pathway; oxidative stress; jak stat ... See more keywords
STAT Signaling in Glioma Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-30651-9_10
Abstract: STAT (signal transducers and activators of transcription) are latent cytoplasmic transcription factors that function as downstream effectors of cytokine and growth factor receptor signaling. The canonical JAK/STAT signaling pathway involves the activation of Janus kinases… read more here.
Keywords: signaling glioma; glioma; stat signaling; glioma cells ... See more keywords
Steroidogenic genes expressions are repressed by high levels of leptin and the JAK/STAT signaling pathway in MA-10 Leydig cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3017-x
Abstract: The adipose tissue is an important endocrine organ secreting numerous peptide hormones, including leptin. Increased circulating levels of leptin, as a result of hormonal resistance in obese individuals, may contribute to lower androgen production in… read more here.
Keywords: levels leptin; high levels; stat signaling; jak stat ... See more keywords
SnapShot: Jak-STAT Signaling II
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.04.052
Abstract: The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory diseases, and hematologic… read more here.
Keywords: stat signaling; jak; snapshot jak; jak stat ... See more keywords
Repeat exposure to polyinosinic:polycytidylic acid induces TLR3 expression via JAK-STAT signaling and synergistically potentiates NFκB-RelA signaling in ARPE-19 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109494
Abstract: Dry age-related macular degeneration (AMD), accounting for approximately 90% of AMD cases, is characterized by photoreceptor death, retinal pigment epithelium (RPE) dysfunction and, ultimately, geographic atrophy - the localized death of RPE leading to loss… read more here.
Keywords: rela; tlr3; stat signaling; exposure ... See more keywords
Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109761
Abstract: Drosophila Vago is a small antiviral peptide. Its ortholog in Culex mosquito was found to be an interferon-like cytokine that limits virus replication through activating Jak/Stat signaling. However, this activation is independent of Domeless, the… read more here.
Keywords: stat signaling; integrin; jak stat; mjvago ... See more keywords
Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173238
Abstract: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLS) play a crucial role in the pathogenesis of RA. RA-FLS display passive pro-inflammatory responses and self-directed aggressive responses, such as pro-inflammatory mediator production, reduced apoptosis and formation of a… read more here.
Keywords: jak; stat signaling; role; peficitinib ... See more keywords
The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.145325
Abstract: COVID-19, a novel identified coronavirus disease due to Severe Acute Respiratory Syndrome coronaviruses 2 (SARS-Cov-2) infection, has posed a significant threat to public health worldwide. It has been reported COVID-19 keeps substantial nucleotide similarity and… read more here.
Keywords: stat signaling; infection; jak stat; signaling pathway ... See more keywords
IL‐9 exhibits elevated expression in osteonecrosis of femoral head patients and promotes cartilage degradation through activation of JAK‐STAT signaling in vitro
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.05.005
Abstract: ABSTRACT Osteonecrosis of the femoral head (ONFH) often causes severe symptoms in young people and limits the mobility of the hip joint. Interleukin‐9 (IL‐9) is a multi‐functional inflammatory factor that participates in lumbar disk herniation… read more here.
Keywords: osteonecrosis; stat signaling; cartilage; jak stat ... See more keywords
FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108117
Abstract: FPS-ZM1 is an inhibitor of the receptor for advanced glycation end products (RAGE). Nevertheless, there are few reports about its direct effects on microglial inflammation, and the underlying molecular mechanisms remain to be clarified. The… read more here.
Keywords: microglial inflammation; stat signaling; fps zm1; signaling pathway ... See more keywords