Proceed with Caution: STAT1 GOF Diagnosis Missed Due to Intronic SNP
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-020-00768-9
Abstract: To the Editor, We present a case of a false-negative predictive test by targeted Sanger sequencing of the signal transducer and activator of transcription 1 (STAT1) gene, due to a heterozygous single nucleotide polymorphism (SNP)… read more here.
Keywords: candidiasis; diagnostic laboratory; stat1; snp ... See more keywords
Successful Hematopoietic Stem Cell Transplantation for Autosomal Recessive STAT1 Complete Deficiency
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-020-00948-7
Abstract: To the Editor: Signal transducer and activator of transcription 1 (STAT1) is a transcription factor that mediates signal transduction via several factors, including interferon (IFN)-α/β and IFN-γ. Germline mutations in STAT1 cause the following four… read more here.
Keywords: complete deficiency; stat1 complete; stat1; hsct ... See more keywords
LncRNA AIRN influences the proliferation and apoptosis of hepatocellular carcinoma cells by regulating STAT1 ubiquitination.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of pharmacal research"
DOI: 10.1007/s12272-021-01317-7
Abstract: Long non-coding RNAs (LncRNAs) have been implicated in the pathogenesis of various human diseases. In this study, we probed into the role and potential mechanisms of the antisense of IGF2R non-protein coding RNA (LncRNA AIRN)… read more here.
Keywords: hepatocellular carcinoma; apoptosis; stat1; proliferation ... See more keywords
STAT1 upregulates glutaminase and modulates amino acids and glutathione metabolism.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.006
Abstract: We previously reported the upregulation of cellular Glu and glutathione levels in human ABCB5- and murine Abcb5-transfected cells. Here, we demonstrate the upregulation of STAT1 and glutaminase (GLS) in ABCB5/Abcb5-transfected cells. Among a total of… read more here.
Keywords: abcb5; high expressing; stat1; resistance ... See more keywords
CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.037
Abstract: Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of signal transducer and activator of transcription 1 (STAT1) and induction of STAT1-regulated genes and that this process… read more here.
Keywords: stat1; cd95 fas; type; cancer cells ... See more keywords
Effects of hypnotic bromovalerylurea on microglial BV2 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.05.007
Abstract: An old sedative and hypnotic bromovalerylurea (BU) has anti-inflammatory effects. BU suppressed nitric oxide (NO) release and proinflammatory cytokine expression by lipopolysaccharide (LPS)-treated BV2 cells, a murine microglial cell line. However, BU did not inhibit… read more here.
Keywords: lps induced; hypnotic bromovalerylurea; stat1; expression ... See more keywords
Tryptanthrin suppresses double-stranded RNA-induced CXCL10 expression via inhibiting the phosphorylation of STAT1 in human umbilical vein endothelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.11.003
Abstract: Tryptanthrin is a bioactive component of indigo plants such as Polygonum tinctrorium and known to have an anti-inflammatory activity. The aim of this study was to investigate the effects of tryptanthrin on Toll-like receptor 3… read more here.
Keywords: vein endothelial; stat1; human umbilical; expression ... See more keywords
Study of the inhibitory effect of STAT1 on PDCoV infection
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Microbiology"
DOI: 10.1016/j.vetmic.2022.109333
Abstract: Porcine deltacoronavirus (PDCoV) is an enteropathogen found in many pig producing countries. It can cause acute diarrhea, vomiting, dehydration, and death in newborn piglets, seriously affecting the development of pig breeding industries. To date, our… read more here.
Keywords: pdcov infection; pdcov; llc pk1; study inhibitory ... See more keywords
Nicotine promotes WRL68 cells proliferation due to the mutant p53 gain-of-function by activating CDK6-p53-RS-PIN1-STAT1 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00119
Abstract: The liver is an important organ with many tasks, such as dealing with drugs, alcohol and other toxins to remove them from the body. Nicotine is the more abundant component in cigarette smoking, which is… read more here.
Keywords: wrl68 cells; stat1; cells proliferation; mutant p53 ... See more keywords
Fludarabine inhibits type I interferon-induced expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-021-00698-5
Abstract: Angiotensin-converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV2 and is upregulated after infection with these viruses, which assists the entry of these viruses into the target cells.… read more here.
Keywords: hbe cells; ifn; stat1; ace2 ... See more keywords
Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA
Sign Up to like & getrecommendations! Published in 2017 at "Nature Immunology"
DOI: 10.1038/s41590-017-0003-0
Abstract: Prolonged activation of interferon–STAT1 signaling is closely related to inflammatory autoimmune disorders, and therefore the identification of negative regulators of these pathways is important. Through high-content screening of 115 mouse RING-domain E3 ligases, we identified… read more here.
Keywords: rnf2; dna; stat1; interferon ... See more keywords