Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction
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DOI: 10.1101/2022.08.09.503314
Abstract: DUX4 activates the first wave of zygotic gene expression in the early embryo. Mis-expression of DUX4 in skeletal muscle causes facioscapulohumeral dystrophy (FSHD), whereas expression in cancers suppresses IFNγ-induction of MHC Class I and contributes… read more here.
Keywords: stat1 broadly; dux4; mouse dux; expression ... See more keywords