Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma
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DOI: 10.1136/gutjnl-2024-332281
Abstract: Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood. Objective We aimed to identify ICB resistance-associated… read more here.
Keywords: hepatocellular carcinoma; icb; stat1 gsdme; gsdme ... See more keywords