Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2016.11.017
Abstract: Autophagy is involved in both innate and adaptive immune regulation. We propose that autophagy regulates activation of TLR3 in macrophages and is thereby essential for development of pristane-induced arthritis. We found that pristane treatment induced… read more here.
Keywords: stat1 irf1; pristane; irf1 tlr3; tlr3 ... See more keywords
Lac water extract inhibits IFN-γ signaling through JAK2-STAT1-IRF1 axis in human melanoma
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra02955e
Abstract: Interferon-γ (IFN-γ) is a cytokine that plays an important role in the host defense of infectious diseases and in immune surveillance during tumor development; however, it has adverse effects in the pathogenesis of autoimmune diseases… read more here.
Keywords: water extract; stat1 irf1; lac water; ifn signaling ... See more keywords
NR4A1 mediates NK‐cell dysfunction in hepatocellular carcinoma via the IFN‐γ/p‐STAT1/IRF1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13611
Abstract: Hepatocellular carcinoma (HCC) is one of the most fatal tumours worldwide and has a high recurrence rate. Nevertheless, the mechanism of HCC genesis remains partly unexplored, while the efficiency of HCC treatments remains limited. The… read more here.
Keywords: hepatocellular carcinoma; ifn stat1; dysfunction; stat1 irf1 ... See more keywords
Verteporfin Inhibits PD-L1 through Autophagy and the STAT1–IRF1–TRIM28 Signaling Axis, Exerting Antitumor Efficacy
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-19-0159
Abstract: Antibody blockade of PD-L1 is associated with toxicities, thus new targeting strategies are needed. Verteporfin suppresses PD-L1 expression via Golgi-related autophagy and disruption of STAT1–IRF1–TRIM28 signaling. Programmed cell death 1 ligand 1 (PD-L1) is a… read more here.
Keywords: irf1 trim28; stat1 irf1; trim28 signaling; verteporfin ... See more keywords