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   Articles with "stat1 irf1" as a keyword



Coptisine Improves Liver Inflammation in Sepsis by Regulating STAT1/IRF1/GPX4 Signaling‐Mediated Kupffer Cells Ferroptosis

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recommendations! Published in 2025 at "Phytotherapy Research"

DOI: 10.1002/ptr.70063

Abstract: Sepsis is a life‐threatening condition characterized by organ dysfunction, with the liver being particularly vulnerable due to inflammation triggered by Kupffer cell activation. Ferroptosis, an iron‐dependent form of regulated cell death associated with macrophages, has… read more here.

Keywords: kupffer; stat1 irf1; ferroptosis; inflammation ... See more keywords

Pristane induces autophagy in macrophages, promoting a STAT1-IRF1-TLR3 pathway and arthritis.

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recommendations! Published in 2017 at "Clinical immunology"

DOI: 10.1016/j.clim.2016.11.017

Abstract: Autophagy is involved in both innate and adaptive immune regulation. We propose that autophagy regulates activation of TLR3 in macrophages and is thereby essential for development of pristane-induced arthritis. We found that pristane treatment induced… read more here.

Keywords: stat1 irf1; pristane; irf1 tlr3; tlr3 ... See more keywords

Lac water extract inhibits IFN-γ signaling through JAK2-STAT1-IRF1 axis in human melanoma

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recommendations! Published in 2018 at "RSC Advances"

DOI: 10.1039/c8ra02955e

Abstract: Interferon-γ (IFN-γ) is a cytokine that plays an important role in the host defense of infectious diseases and in immune surveillance during tumor development; however, it has adverse effects in the pathogenesis of autoimmune diseases… read more here.

Keywords: water extract; stat1 irf1; lac water; ifn signaling ... See more keywords

NR4A1 mediates NK‐cell dysfunction in hepatocellular carcinoma via the IFN‐γ/p‐STAT1/IRF1 pathway

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recommendations! Published in 2022 at "Immunology"

DOI: 10.1111/imm.13611

Abstract: Hepatocellular carcinoma (HCC) is one of the most fatal tumours worldwide and has a high recurrence rate. Nevertheless, the mechanism of HCC genesis remains partly unexplored, while the efficiency of HCC treatments remains limited. The… read more here.

Keywords: hepatocellular carcinoma; ifn stat1; dysfunction; stat1 irf1 ... See more keywords

Verteporfin Inhibits PD-L1 through Autophagy and the STAT1–IRF1–TRIM28 Signaling Axis, Exerting Antitumor Efficacy

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recommendations! Published in 2020 at "Cancer Immunology Research"

DOI: 10.1158/2326-6066.cir-19-0159

Abstract: Antibody blockade of PD-L1 is associated with toxicities, thus new targeting strategies are needed. Verteporfin suppresses PD-L1 expression via Golgi-related autophagy and disruption of STAT1–IRF1–TRIM28 signaling. Programmed cell death 1 ligand 1 (PD-L1) is a… read more here.

Keywords: irf1 trim28; stat1 irf1; trim28 signaling; verteporfin ... See more keywords