Human Disease Phenotypes Associated with Loss and Gain of Function Mutations in STAT2: Viral Susceptibility and Type I Interferonopathy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-021-01118-z
Abstract: STAT2 is distinguished from other STAT family members by its exclusive involvement in type I and III interferon (IFN-I/III) signaling pathways, and its unique behavior as both positive and negative regulator of IFN-I signaling. The… read more here.
Keywords: type interferonopathy; susceptibility; disease; stat2 ... See more keywords
IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive IL6 expression
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1714102115
Abstract: Significance We describe unexpected cooperation between two cytokines that are important in regulating the growth of cancers, namely, type I interferons (IFNs) and interleukin 6 (IL6). It is well established that IL6 is vital for… read more here.
Keywords: irf9 unphosphorylated; il6; stat2; il6 expression ... See more keywords
STAT2/Caspase3 in the diagnosis and treatment of psoriasis
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.13959
Abstract: Psoriasis is a classic chronic recurrent inflammatory skin disease characterized by skin inflammation and abnormal biological behaviour of keratinocytes. Although Signal Transducer And Activator Of Transcription 2 (STAT2) was found to play an important role… read more here.
Keywords: stat2 caspase3; treatment psoriasis; diagnosis treatment; stat2 ... See more keywords
African swine fever virus ubiquitin-conjugating enzyme pI215L inhibits IFN-I signaling pathway through STAT2 degradation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1081035
Abstract: African swine fever virus (ASFV) is the causative agent of one of the most lethal diseases affecting domestic pig and wild boar, which is endangering the swine industry due to its rapid expansion. ASFV has… read more here.
Keywords: conjugating enzyme; stat2; ifn; ubiquitin conjugating ... See more keywords
Downregulation of nuclear STAT2 protein in the spinal dorsal horn is involved in neuropathic pain following chronic constriction injury of the rat sciatic nerve
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1069331
Abstract: Regulation of gene transcription in the spinal dorsal horn (SDH) plays a critical role in the pathophysiology of neuropathic pain. In this study, we investigated whether the transcription factor STAT2 affects neuropathic pain and evaluated… read more here.
Keywords: stat2; constriction injury; neuropathic pain; pain ... See more keywords
STAT2 Limits Host Species Specificity of Human Metapneumovirus
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DOI: 10.3390/v12070724
Abstract: The host tropism of viral infection is determined by a variety of factors, from cell surface receptors to innate immune signaling. Many viruses encode proteins that interfere with host innate immune recognition in order to… read more here.
Keywords: infection; stat2; host; stat2 limits ... See more keywords