Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints
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DOI: 10.1038/s41467-024-49758-0
Abstract: Zika and dengue virus nonstructural protein 5 antagonism of STAT2, a critical interferon signaling transcription factor, to suppress the host interferon response is required for viremia and pathogenesis in a vertebrate host. This affects viral… read more here.
Keywords: evolution; stat2 resistance; resistance; resistance flavivirus ... See more keywords