PTMA controls cardiomyocyte proliferation and cardiac repair by enhancing STAT3 acetylation
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adt9446
Abstract: The adult mammalian heart has limited regenerative capacity due to the low proliferative ability of cardiomyocytes, whereas embryonic cardiomyocytes exhibit robust proliferative potential. Using single-cell RNA sequencing of embryonic hearts, we identified prothymosin α (PTMA)… read more here.
Keywords: heart; ptma; cardiomyocyte proliferation; stat3 acetylation ... See more keywords
The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0359
Abstract: Epigenetic silencing of promoter and enhancer regions is a common phenomenon in malignant cells. The transcription factor STAT3 is aberrantly activated in several tumors, where its constitutive acetylation accounts for the transcriptional repression of a… read more here.
Keywords: stat3; stat3 acetylation; sin3a; cell ... See more keywords