A Dual-Targeting Liposome Enhances Triple-Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202302834
Abstract: Immunotherapy gains increasing focus in treating triple-negative breast cancer (TNBC), while its efficacy is greatly restricted owing to low tumor immunogenicity and immunosuppressive tumor microenvironment (ITM). Herein, a LyP-1 and chondroitin sulfate (CS) dual-modified liposome… read more here.
Keywords: cell; stat3 activation; triple negative; chemoimmunotherapy ... See more keywords
Licorice Extracts Attenuate Nephrotoxicity Induced by Brucine Through Suppression of Mitochondria Apoptotic Pathway and STAT3 Activation
Sign Up to like & getrecommendations! Published in 2019 at "Current Medical Science"
DOI: 10.1007/s11596-019-2126-z
Abstract: Licorice, one of the most widely used medicinal herbs in East Asia, has effects such as anti-inflammation, antioxidant, and detoxifying. This study aimed to evaluate the protective effect of licorice on brucine-induced nephrotoxicity. Sprague Dawley… read more here.
Keywords: stat3 activation; brucine; licorice; nephrotoxicity ... See more keywords
Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP‐2 tyrosine phosphatase
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.06.131
Abstract: ABSTRACT The roles and significance of signal transducer and activator of transcription 3 (STAT3) in human cancers have been extensively studied and STAT3 is a promising therapeutic target for cancer drug discovery. During the screening… read more here.
Keywords: cg902; geranylnaringenin cg902; activation; stat3 activation ... See more keywords
Gestational zinc deficiency impairs brain astrogliogenesis in rats through multistep alterations of the JAK/STAT3 signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102017
Abstract: We previously showed that zinc (Zn) deficiency affects the STAT3 signaling pathway in part through redox-regulated mechanisms. Given that STAT3 is central to the process of astrogliogenesis, this study investigated the consequences of maternal marginal… read more here.
Keywords: zinc deficiency; astrogliogenesis; brain; stat3 activation ... See more keywords
E069 Antagonism of IL-27 bioactivity
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead104.318
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease that results in joint damage and bony destruction. The inflammatory process is central in the pathology of RA, with cytokines mediating the inflammatory response. Cytokines, in particular… read more here.
Keywords: bioactivity antagonist; activation; stat3 activation; antagonism bioactivity ... See more keywords
TRIM27‐USP7 complex promotes tumour progression via STAT3 activation in human hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15346
Abstract: TRIM27 is stabilized by binding to USP7 and mediates tumour progression in several cancers; however, the roles of TRIM27‐USP7 complex on STAT3 activation in HCC are unknown. read more here.
Keywords: usp7 complex; tumour progression; trim27 usp7; stat3 activation ... See more keywords
Adiponectin Facilitates Postconditioning Cardioprotection through Both AMPK-Dependent Nuclear and AMPK-Independent Mitochondrial STAT3 Activation
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/4253457
Abstract: Myocardial ischemic postconditioning- (IPo-) mediated cardioprotection against myocardial ischemia-reperfusion (IR) injury needs the activation of signal transducer and activator of transcription 3 (STAT3), which involves adiponectin (APN). APN confers its biological effects through AMP-activated protein… read more here.
Keywords: ipo; ampk independent; activation; stat3 activation ... See more keywords
Abstract 2782: Small molecule H182 suppresses Stat3 activation in tumor cells and combines with radiation therapy to block breast tumor growth in mouse syngeneic models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2782
Abstract: Signal transducer and activator of transcription 3 (Stat3) is a latent transcription factor that contributes to tumor cell growth and survival in constitutively-active form in several types of human cancers, and hence, serves as a… read more here.
Keywords: stat3 activation; breast; tumor; h182 ... See more keywords
Abstract 6149: STAT3 activation promotes invasiveness and cancer stemness in lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6149
Abstract: Lung cancer is the leading cause of cancer-related death worldwide, featuring a high incidence and low 5-year survival rate. Nearly 40% of patients are diagnosed with metastatic disease when they are first presented to the… read more here.
Keywords: lung cancer; cancer stemness; cancer; stat3 activation ... See more keywords
SHP-1 alleviates atrial fibrosis in atrial fibrillation by modulating STAT3 activation.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental biology and medicine"
DOI: 10.1177/15353702231165717
Abstract: Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1) has a well-established role in myocardial infarction, yet its involvement in atrial fibrosis and atrial fibrillation (AF) has not been elucidated. As cardiac arrhythmias caused by… read more here.
Keywords: shp; ang treated; atrial fibrosis; stat3 activation ... See more keywords
IL-6-DEPENDENT STAT3 ACTIVATION AND INDUCTION OF PROINFLAMMATORY CYTOKINES IN PRIMARY SCLEROSING CHOLANGITIS.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and translational gastroenterology"
DOI: 10.14309/ctg.0000000000000603
Abstract: OBJECTIVES Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease with periductal inflammation and fibrosis. Genetic studies suggest inflammatory cytokines and IL-6-dependent activation of transcription factor STAT3 as pivotal steps in PSC pathogenesis. However,… read more here.
Keywords: stat3 activation; sclerosing cholangitis; stat3; primary sclerosing ... See more keywords