Exercise activates the hypothalamic S1PR1–STAT3 axis through the central action of interleukin 6 in mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26818
Abstract: Hypothalamic sphingosine‐1‐phosphate receptor 1 (S1PR1), the G protein–coupled receptor 1 of sphingosine‐1‐phosphate, has been described as a modulator in the control of energy homeostasis in rodents. However, this mechanism is still unclear. Here, we evaluate… read more here.
Keywords: stat3 axis; mice; s1pr1; exercise ... See more keywords
IL6/STAT3 axis mediates resistance to BRAF inhibitors in thyroid carcinoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.038
Abstract: Thyroid carcinomas (TCs) bearing BRAF mutations represent approximately 26-53% of human thyroid malignancies and, differently from melanomas, are poorly sensitive to BRAF inhibitors (BRAFi), and develop acquired resistance through activation of alternative signaling pathways. A… read more here.
Keywords: plx4032; braf; stat3 axis; il6 stat3 ... See more keywords
CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107657
Abstract: Neuroinflammation is a crucial mechanism in many neurological disorders. Injury to the peripheral sensory nerves leads to a neuroinflammatory response in the somatosensory pathway, from dorsal root ganglia (DRG) to the spinal cord, contributing to… read more here.
Keywords: cntf stat3; mediates neuroinflammatory; stat3 axis; cntf ... See more keywords
The JAK/STAT3 axis: A comprehensive drug target for solid malignancies.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.06.001
Abstract: Intercellular communication between tumor cells, immune cells and the stroma characterises the tumor microenvironment, which is instrumental for establishing the ecological niche that fosters tumor growth and metastasis. While tumor cell intrinsic STAT3 signaling provides… read more here.
Keywords: axis comprehensive; stat3; stat3 axis; jak stat3 ... See more keywords
An HLA-G/SPAG9/STAT3 axis promotes brain metastases
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205247120
Abstract: Significance Current treatment options for Brain Metastases (BM) still result in reduced survival outcomes in affected patients, emphasizing the need for a better understanding of the disease and consequently more efficient therapies. In this study,… read more here.
Keywords: spag9 stat3; brain metastases; brain; stat3 axis ... See more keywords
Role of IL-6/STAT3 Axis in Resistance to Cisplatin in Gastric Cancers
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11030694
Abstract: Gastric cancer, the second most common cause of death worldwide, is characterized by poor prognosis and low responsiveness to chemotherapy. Indeed, multidrug resistance, based mainly on cellular and molecular factors, remains one of the most… read more here.
Keywords: stat3 axis; cisplatin; resistance; gastric cancer ... See more keywords
IL-6/STAT3 Axis Activates Glut5 to Regulate Fructose Metabolism and Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.68990
Abstract: Cancer cells frequently use fructose as an alternative energy and carbon source, to fuel glycolysis and support the synthesis of various biomacromolecules. Glut5 is the only fructose-specific transporter, which lacks the ability to transport other… read more here.
Keywords: cancer; stat3 axis; axis activates; fructose metabolism ... See more keywords