SIGIRR mutation identified in human necrotizing enterocolitis (NEC) disrupts STAT3-dependent microRNA expression in neonatal gut.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular gastroenterology and hepatology"
DOI: 10.1016/j.jcmgh.2021.09.009
Abstract: BACKGROUND AND AIMS Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR) is a major inhibitor of Toll-like Receptor (TLR) signaling. Our laboratory identified a novel SIGIRR stop mutation (p.Y168X) in an infant who succumbed to severe NEC.… read more here.
Keywords: expression; neonatal gut; sigirr; stat3 dependent ... See more keywords
Onco-miR-21 Promotes Stat3-Dependent Gastric Cancer Progression
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14020264
Abstract: Simple Summary MicroRNAs (miRNAs) are a class of highly conserved small, non-protein coding RNAs with often-deregulated expression in cancer. miR-21 is a well-studied cancer-associated microRNA which is able to regulate proliferation, apoptosis, and invasion. The… read more here.
Keywords: cancer progression; gastric cancer; mir; stat3 dependent ... See more keywords