PA03 Should patients with atopic dermatitis be screened for genes associated with hyper-IgE syndrome?
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Dermatology"
DOI: 10.1093/bjd/ljae090.258
Abstract: Individuals with severe atopic dermatitis (AD) may present with very high serum IgE levels (> 10 000 IU mL−1). Signal transducer and activator of transcription 3 hyper-IgE syndrome (STAT3-HIES), a rare immunosuppressive disorder, shares pathogenic similarities… read more here.
Keywords: ige levels; hyper ige; stat3 hies; stat3 ... See more keywords
STAT3-dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome.
Sign Up to like & getrecommendations! Published in 2025 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202407-1415oc
Abstract: RATIONALE Hyper IgE syndrome (STAT3-HIES), also known as Job's syndrome, is a rare immunodeficiency disease typically caused by dominant-negative STAT3 mutations. STAT3-HIES is characterized by chronic pulmonary infection and inflammation, suggesting impaired innate host defense.… read more here.
Keywords: hyper ige; stat3 hies; syndrome; innate ... See more keywords
Clinical Profile of Hyper-IgE Syndrome in India
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DOI: 10.3389/fimmu.2021.626593
Abstract: Introduction: Hyper-IgE Syndrome (HIES) is a rare inborn error of immunity (IEI) characterized by a constellation of symptoms related to susceptibility to Staphylococcal skin and pulmonary infections, eczema, raised serum IgE (>2,000 IU/ml), craniofacial anomalies,… read more here.
Keywords: hyper ige; stat3 hies; ige syndrome; exon exon ... See more keywords