P-STAT3 Inhibition Activates Endoplasmic Reticulum Stress-Induced Splenocyte Apoptosis in Chronic Stress
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DOI: 10.3389/fphys.2020.00680
Abstract: Chronic stress leads to immunosuppression and induces splenocyte apoptosis. STAT3 is a transcription factor that regulates immunity and apoptosis; however, it is unclear whether the increased expression of phosphorylated STAT3 (p-STAT3) observed in chronic stress… read more here.
Keywords: chronic stress; stress; splenocyte apoptosis; stat3 inhibition ... See more keywords
STAT3 Inhibition Attenuates MYC Expression by Modulating Co-Activator Recruitment and Suppresses Medulloblastoma Tumor Growth by Augmenting Cisplatin Efficacy In Vivo
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DOI: 10.3390/cancers15082239
Abstract: Simple Summary Medulloblastoma (MB) is a malignant brain tumor of childhood that occurs in the cerebellum and accounts for 20–25% of all pediatric central nervous system tumors. Despite improvement in overall survival rate, it still… read more here.
Keywords: stat3 inhibition; expression; efficacy; inhibition attenuates ... See more keywords