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   Articles with "stat3 inhibitors" as a keyword



MAPK and STAT3 Inhibitors Modulate FoxP3 Expression and Regulatory T Cell Function

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recommendations! Published in 2025 at "European Journal of Immunology"

DOI: 10.1002/eji.202451225

Abstract: Regulatory T cells (Tregs) are a subset of T cells defined by the expression of Forkhead box protein P3 (FoxP3) playing a crucial role in regulating effector T cell activity. Tregs accumulate in the tumor… read more here.

Keywords: foxp3 expression; cell; expression; mapk stat3 ... See more keywords

Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities

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recommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"

DOI: 10.1007/s00262-017-1966-2

Abstract: Immunotherapies emerged as an alternative for cancer treatment, yet their clinical efficacies are still limited, especially in case of solid tumors. Myeloid immune cells, such as macrophages and myeloid-derived suppressor cells (MDSCs), are often hijacked… read more here.

Keywords: myeloid cells; oligonucleotide therapeutics; stat3; cancer ... See more keywords
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Discovery of new benzensulfonamide derivatives as tripedal STAT3 inhibitors.

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recommendations! Published in 2018 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2018.03.053

Abstract: Persistent activated STAT3 has a striking correlation with cancer development and inhibition of STAT3 signaling pathway is a novel therapeutic way for human cancers. Among STAT family, STAT1 and STAT3 play opposite roles in tumorigenesis.… read more here.

Keywords: discovery new; new benzensulfonamide; derivatives tripedal; stat3 ... See more keywords

STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions

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recommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"

DOI: 10.1016/j.jpba.2018.07.018

Abstract: HIGHLIGHTSTruncated variants of STAT3 allowed the development of conventional STAT3 thermal stability assays.Thermal denaturing of STAT3 can be tracked using Sypro OrangeTM fluorescence, tryptophan fluorescence or light scattering.Novel thermal stability assays confirm that peptide STAT3… read more here.

Keywords: protein; differential scanning; stat3; stat3 inhibitors ... See more keywords

A Multi-input Deep Learning Architecture for STAT3 Inhibitor Prediction

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recommendations! Published in 2025 at "ACS Omega"

DOI: 10.1021/acsomega.5c05380

Abstract: Signal transducer and activator of transcription 3 (STAT3) is a critical factor involved in various physiological and oncogenic signaling pathways. Machine learning models are valuable tools for predicting or screening STAT3 inhibitors. However, the predictive… read more here.

Keywords: stat3 inhibitor; inhibitor prediction; model; stat3 ... See more keywords
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Discovery of new STAT3 inhibitors as anticancer agents using ligand-receptor contact fingerprints and docking-augmented machine learning

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recommendations! Published in 2023 at "RSC Advances"

DOI: 10.1039/d2ra07007c

Abstract: STAT3 belongs to a family of seven vital transcription factors. High levels of STAT3 are detected in several types of cancer. Hence, STAT3 inhibition is considered a promising therapeutic anti-cancer strategy. In this work, we… read more here.

Keywords: ligand receptor; machine; machine learning; stat3 ... See more keywords
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Novel inhibitors of the STAT3 signaling pathway: an updated patent review (2014-present).

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recommendations! Published in 2022 at "Expert opinion on therapeutic patents"

DOI: 10.1080/13543776.2022.2056013

Abstract: INTRODUCTION STAT3 is a critical transcription factor that transmits signals from the cell surface to the nucleus, thus influencing the transcriptional regulation of some oncogenes. The inhibition of the activation of STAT3 is considered a… read more here.

Keywords: review; stat3 inhibitors; stat3 signaling; signaling pathway ... See more keywords

Discovery of STAT3 Inhibitors: Recent Advances and Future Perspective.

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recommendations! Published in 2022 at "Current medicinal chemistry"

DOI: 10.2174/0929867329666220819093117

Abstract: BACKGROUND STAT3 (signal transducer and activator of transcription 3) is a member of the STAT family of proteins that function as signal transducers and transcription factors. Previous research has demonstrated its importance in cell proliferation,… read more here.

Keywords: stat3; stat3 inhibitors; discovery stat3; inhibitors recent ... See more keywords

The Antiproliferative and Colony-suppressive Activities of STAT3 Inhibitors in Human Cancer Cells Is Compromised Under Hypoxic Conditions.

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recommendations! Published in 2017 at "Anticancer research"

DOI: 10.21873/anticanres.11347

Abstract: Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been indicated as a novel cancer drug target, since it plays an important role in diverse oncogenic processes including survival, cell proliferation and… read more here.

Keywords: colony; hypoxic conditions; cancer cells; stat3 inhibitors ... See more keywords