Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-1966-2
Abstract: Immunotherapies emerged as an alternative for cancer treatment, yet their clinical efficacies are still limited, especially in case of solid tumors. Myeloid immune cells, such as macrophages and myeloid-derived suppressor cells (MDSCs), are often hijacked… read more here.
Keywords: myeloid cells; oligonucleotide therapeutics; stat3; cancer ... See more keywords
Discovery of new benzensulfonamide derivatives as tripedal STAT3 inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.053
Abstract: Persistent activated STAT3 has a striking correlation with cancer development and inhibition of STAT3 signaling pathway is a novel therapeutic way for human cancers. Among STAT family, STAT1 and STAT3 play opposite roles in tumorigenesis.… read more here.
Keywords: discovery new; new benzensulfonamide; derivatives tripedal; stat3 ... See more keywords
STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.07.018
Abstract: HIGHLIGHTSTruncated variants of STAT3 allowed the development of conventional STAT3 thermal stability assays.Thermal denaturing of STAT3 can be tracked using Sypro OrangeTM fluorescence, tryptophan fluorescence or light scattering.Novel thermal stability assays confirm that peptide STAT3… read more here.
Keywords: protein; differential scanning; stat3; stat3 inhibitors ... See more keywords
Discovery of new STAT3 inhibitors as anticancer agents using ligand-receptor contact fingerprints and docking-augmented machine learning
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra07007c
Abstract: STAT3 belongs to a family of seven vital transcription factors. High levels of STAT3 are detected in several types of cancer. Hence, STAT3 inhibition is considered a promising therapeutic anti-cancer strategy. In this work, we… read more here.
Keywords: ligand receptor; machine; machine learning; stat3 ... See more keywords
Novel inhibitors of the STAT3 signaling pathway: an updated patent review (2014-present).
Sign Up to like & getrecommendations! Published in 2022 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2022.2056013
Abstract: INTRODUCTION STAT3 is a critical transcription factor that transmits signals from the cell surface to the nucleus, thus influencing the transcriptional regulation of some oncogenes. The inhibition of the activation of STAT3 is considered a… read more here.
Keywords: review; stat3 inhibitors; stat3 signaling; signaling pathway ... See more keywords
Discovery of STAT3 Inhibitors: Recent Advances and Future Perspective.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220819093117
Abstract: BACKGROUND STAT3 (signal transducer and activator of transcription 3) is a member of the STAT family of proteins that function as signal transducers and transcription factors. Previous research has demonstrated its importance in cell proliferation,… read more here.
Keywords: stat3; stat3 inhibitors; discovery stat3; inhibitors recent ... See more keywords
The Antiproliferative and Colony-suppressive Activities of STAT3 Inhibitors in Human Cancer Cells Is Compromised Under Hypoxic Conditions.
Sign Up to like & getrecommendations! Published in 2017 at "Anticancer research"
DOI: 10.21873/anticanres.11347
Abstract: Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been indicated as a novel cancer drug target, since it plays an important role in diverse oncogenic processes including survival, cell proliferation and… read more here.
Keywords: colony; hypoxic conditions; cancer cells; stat3 inhibitors ... See more keywords