Ginsenoside RD prevents acute liver injury in mice by inhibiting STAT3‐mediated NLRP3/GSDMD activation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23825
Abstract: We investigated the role and mechanism of ginsenoside RD (GRD) in acute liver injury. Network pharmacology was used to analyze the correlations among GRD‐liver injury‐pyroptosis targets. A mouse model of acute liver injury was established… read more here.
Keywords: mice; acute liver; liver injury; injury ... See more keywords
STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2016.1259037
Abstract: ABSTRACT Cytokines in the developing tumor microenvironment (TME) can drive transformation and subsequent progression toward metastasis. Elevated levels of the Interleukin-6 (IL-6) family cytokine Oncostatin M (OSM) in the breast TME correlate with aggressive, metastatic… read more here.
Keywords: senescence; stat3; induced senescence; stat3 mediated ... See more keywords
Expression of NEAT1 induced by influenza virus infection is regulated by activated STAT3 and contributes to STAT3-mediated antiviral immunity
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1693884
Abstract: The transcription factor STAT3 is integral to the immune response during viral infections, while long non-coding RNAs (lncRNAs) are actively implicated in the modulation of viral pathogenesis. However, the relationship between STAT3 and lncRNAs during… read more here.
Keywords: infection; stat3 mediated; influenza virus; expression neat1 ... See more keywords
Epigallocatechin-3-Gallate (EGCG)-Inducible SMILE Inhibits STAT3-Mediated Hepcidin Gene Expression
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9060514
Abstract: Hepatic peptide hormone hepcidin, a key regulator of iron metabolism, is induced by inflammatory cytokine interleukin-6 (IL-6) in the pathogenesis of anemia of inflammation or microbial infections. Small heterodimer partner-interacting leucine zipper protein (SMILE)/CREBZF is… read more here.
Keywords: mediated hepcidin; epigallocatechin gallate; hepcidin gene; expression ... See more keywords
STAT3 Mediated miR-30a-5p Inhibition Enhances Proliferation and Inhibits Apoptosis in Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21197315
Abstract: Signal transducer and activator of transcription 3 (STAT3), a transcriptional factor involved in tumorigenesis and cancer stemness formation, contributes to drug resistance in cancer therapies. STAT3 not only mediates gene transcription but also participates in… read more here.
Keywords: stat3 mediated; hsa mir; colorectal cancer; derived tumorspheres ... See more keywords