OS06.7 PI-3Kγ inhibition suppresses glioblastoma tumorigenicity through disruption of an IL11-STAT3-MYC signaling axis between microglia and glioblastoma.
Sign Up to like & getrecommendations! Published in 2017 at "Neuro-oncology"
DOI: 10.1093/neuonc/nox036.041
Abstract: AbstractWhile mutations in isocitrate dehydrogenase (IDH) gene are associated with favorable prognosis in glioblastoma patients, the biologic basis for favorable survival in patients with wild-type IDH (wtIDH) glioblastoma remains poorly understood. We identified that an… read more here.
Keywords: glioblastoma tumorigenicity; glioblastoma; il11; stat3 myc ... See more keywords
GINS2 Promotes Osteosarcoma Tumorigenesis via STAT3/MYC Axis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Oncology"
DOI: 10.1155/2023/8454142
Abstract: GINS2 is overexpressed in several cancers, but little is known about its role in osteosarcoma (OS). A series of in vivo and in vitro experiments were conducted to explore the role of GINS2 in OS.… read more here.
Keywords: myc axis; myc; gins2; stat3 myc ... See more keywords
Transcription Factors STAT3 and MYC Are Key Players of Human Platelet Lysate-Induced Cell Proliferation
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DOI: 10.3390/ijms232415782
Abstract: Human platelet lysate (HPL) is an efficient alternative for animal serum supplements, significantly enhancing stromal cell proliferation. However, the molecular mechanism behind this growth-promoting effect remains elusive. The aim of this study was to investigate… read more here.
Keywords: cell; cell proliferation; hpl; expression ... See more keywords