Exercise preconditioning attenuates cerebral ischemia-induced neuronal apoptosis, Th17/Treg imbalance, and inflammation in rats by inhibiting the JAK2/STAT3 pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Brain and behavior"
DOI: 10.1002/brb3.3030
Abstract: BACKGROUND Exercise preconditioning (EP) is essential for preventing ischemic stroke. Recent studies have shown that EP exerts neuroprotective effects in the cerebral ischemia-reperfusion injury model. Nonetheless, there have been few reports on the relationship between… read more here.
Keywords: th17 treg; jak2 stat3; group; jak2 ... See more keywords
HIF‐1α facilitates osteocyte‐mediated osteoclastogenesis by activating JAK2/STAT3 pathway in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28721
Abstract: Osteocytes, entrapped within the mineralized bone matrix, has been found to have numerous functions such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity and also functioning as… read more here.
Keywords: hif; jak2 stat3; rankl; stat3 pathway ... See more keywords
Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21950
Abstract: Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic transcription factor that promotes the transcription of genes associated with… read more here.
Keywords: progression; regulators stat3; noncoding rnas; stat3 pathway ... See more keywords
IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6‐dependent STAT3 pathway
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Toxicology"
DOI: 10.1002/tox.24106
Abstract: Ulcerative colitis (UC) is an idiopathic chronic intestinal inflammation. An increasing body of evidence shows that macrophages play an important role in the pathogenesis of UC. Interferon regulatory factor 4 (IRF4) is crucial for the… read more here.
Keywords: macrophage polarization; irf4; stat3 pathway; ulcerative colitis ... See more keywords
PKM2 promotes cell metastasis and inhibits autophagy via the JAK/STAT3 pathway in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-04041-w
Abstract: Pyruvate kinase M2 (PKM2) is a member of the pyruvate kinase family. It has been recently reported that PKM2 displays non-metabolic activities. Nevertheless, understanding of the role of PKM2 in hepatocellular carcinoma (HCC) is insufficient.… read more here.
Keywords: pkm2; hcc; jak stat3; stat3 pathway ... See more keywords
Effect of electroacupuncture on JAK2/STAT3 pathway in synovial tissues of rats with rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Acupuncture and Tuina Science"
DOI: 10.1007/s11726-019-1121-z
Abstract: To observe the effect of electroacupuncture (EA) on Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway in knee joint synovial tissues of rats with rheumatoid arthritis (RA) and to explore the action… read more here.
Keywords: jak2 stat3; stat3 pathway; group; drug group ... See more keywords
N-3 polyunsaturated fatty acid-enriched lipid emulsion improves Paneth cell function via the IL-22/Stat3 pathway in a mouse model of total parenteral nutrition.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.032
Abstract: Total parenteral nutrition (TPN) is a life-saving therapy for patients with gastrointestinal dysfunction or failure. Long-term TPN impairs gut barrier function and contributes to infections and poor clinical outcomes. However, the underlying mechanisms of TPN-related… read more here.
Keywords: parenteral nutrition; stat3 pathway; paneth cell; total parenteral ... See more keywords
IL-37 mediates the anti-tumor activity in non-small cell lung cancer through IL-6/STAT3 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Biomedicine"
DOI: 10.1016/j.jab.2017.04.001
Abstract: The occurrence and development of lung cancer is closely related to inflammation. Thus, we conducted the present study to investigate the effects of IL-37 (Interleukin 37), a newly identified anti-inflammatory factor, on non-small cell lung… read more here.
Keywords: stat3 pathway; lung cancer; cancer; cell ... See more keywords
Podocarpusflavone A inhibits cell growth of skin cutaneous melanoma by suppressing STAT3 signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.10.008
Abstract: BACKGROUND JAK2/STAT3 pathway is involved in the development and progression of melanoma once DNA damage is caused by environment and genetic factors. OBJECTIVE Here, we aimed to identify novel inhibitor of JAK2/STAT3 pathway and reveal… read more here.
Keywords: melanoma; jak2 stat3; stat3 pathway; pcfa ... See more keywords
Modified Simiaowan Prevents Articular Cartilage Injury in Experimental Gouty Arthritis by Negative Regulation of STAT3 Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.113825
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Modified Simiaowan (MSW) is a traditional Chinese medicine formula that composes of six herbs. It has been widely used in the treatment of gouty arthritis. AIM OF THE STUDY This study was designed… read more here.
Keywords: gouty arthritis; arthritis; modified simiaowan; stat3 pathway ... See more keywords
Early Growth Response Protein 1 Knockdown Alleviates the Cerebral Injury in Rats with Intracerebral Hemorrhage (ICH) via STAT3/NF-κB Pathway by Reducing RXRα Acetylation Level
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2021.02.011
Abstract: Brain EGR1 (early growth response protein 1) overexpression aggravates focal ischemic brain injury, but its role in intracerebral hemorrhage (ICH) induced cerebral injury remains obscure. In this study, a rat ICH model was established by… read more here.
Keywords: acetylation level; brain; rxr acetylation; stat3 pathway ... See more keywords