EGF receptor inhibitors comprehensively suppress hepatitis B virus by downregulation of STAT3 phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2020.100763
Abstract: Current antiviral therapy can not cure chronic hepatitis B virus (HBV) infection or eliminate the risk of hepatocellular carcinoma. The licensed epidermal growth factor receptor (EGFR) inhibitors have found to inhibit hepatitis C virus replication… read more here.
Keywords: egfr inhibitors; hbv; hepatitis virus; stat3 phosphorylation ... See more keywords
Th-17 regulatory cytokines IL-21, IL-23, and IL-6 enhance neutrophil production of IL-17 cytokines during asthma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Asthma"
DOI: 10.1080/02770903.2017.1283696
Abstract: ABSTRACT Background: In a subset of severe asthma patients, chronic airway inflammation is associated with infiltration of neutrophils, Th-17 cells and elevated expression of Th-17-derived cytokines (e.g., interleukin [IL]-17, IL-21, IL-22). Peripheral neutrophils from allergic… read more here.
Keywords: asthma regulatory; production; stat3 phosphorylation; regulatory cytokines ... See more keywords
CYTL1 inhibits tumor metastasis with decreasing STAT3 phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "OncoImmunology"
DOI: 10.1080/2162402x.2019.1577126
Abstract: ABSTRACT CYTL1 is a novel cytokine that was first identified in CD34+ hematopoietic cells. We previously prepared recombinant CYTL1 and verified that it chemoattracted human monocytes via the CCR2/ERK pathway. It has been reported that… read more here.
Keywords: metastasis; cytl1; tumor metastasis; stat3 phosphorylation ... See more keywords
Repurposing anthelmintic praziquantel to treat psoriasis.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15652
Abstract: BACKGROUND AND PURPOSE The anthelmintic drug praziquantel (PZQ) has been used as a standard treatment for schistosomiasis for over 40 years. This study aimed to repurpose PZQ to treat psoriasis. EXPERIMENTAL APPROACH Psoriasis-like skin inflammation… read more here.
Keywords: stat3 phosphorylation; praziquantel; psoriasis; treat psoriasis ... See more keywords
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02522
Abstract: In gut epithelium, IL-22 transmits signals through STAT3 phosphorylation (pSTAT3) which provides intestinal immunity. Many components in the IL-22-pSTAT3 pathway have been identified as risk factors for inflammatory bowel disease (IBD) and some of them… read more here.
Keywords: pstat3 signaling; atf3; immunity; stat3 phosphorylation ... See more keywords
Cryptococcus neoformans Infection Induces IL-17 Production by Promoting STAT3 Phosphorylation in CD4+ T Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.872286
Abstract: Cryptococcus neoformans infection in the central nervous system is a severe infectious disease with poor outcomes and high mortality. It has been estimated that there are 220,000 new cases each year. Over 90% of C.… read more here.
Keywords: neoformans infection; cd4 cells; stat3 phosphorylation; production ... See more keywords
Malate-Aspartate Shuttle Plays an Important Role in LPS-Induced Neuroinflammation of Mice Due to its Effect on STAT3 Phosphorylation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.655687
Abstract: Neuroinflammation is a key pathological factor in numerous neurological disorders. Cumulating evidence has indicated critical roles of NAD+/NADH metabolism in multiple major diseases, while the role of malate-aspartate shuttle (MAS) - a major NADH shuttle… read more here.
Keywords: lps induced; lps; stat3 phosphorylation; induced neuroinflammation ... See more keywords