ZIPK activates the IL‐6/STAT3 signaling pathway and promotes cisplatin resistance in gastric cancer cells
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DOI: 10.1002/2211-5463.13270
Abstract: Gastric cancer is one of the most common malignant cancers globally. Chemotherapy resistance remains a major obstacle in the treatment of gastric cancer, and the molecular mechanisms underlying drug resistance are still not well understood.… read more here.
Keywords: gastric cancer; zipk; signaling pathway; resistance ... See more keywords
Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1847
Abstract: Traumatic brain injury (TBI) has ranked as one of the leading causes of disability and death in the world. The neuroinflammation mediated by signal transducer and activator of transcription 3 (STAT3) signaling during the progression… read more here.
Keywords: traumatic brain; inhibition rnf6; brain injury; brain ... See more keywords
C-terminal of E1A binding protein 2 promotes the malignancy of osteosarcoma cells via JAK1/Stat3 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-019-00523-9
Abstract: Previous studies have demonstrated that the C-terminal of E1A binding proteins (CtBPs) influences tumorigenesis by participating in cell signal transduction in various human malignancies. However, the detailed expression patterns of CtBP isoforms in human osteosarcoma… read more here.
Keywords: ctbp2; expression; jak1 stat3; cell ... See more keywords
PAI-1/PIAS3/Stat3/miR-34a forms a positive feedback loop to promote EMT-mediated metastasis through Stat3 signaling in Non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.014
Abstract: AIM This study intented to clarify the intracellular effect of PAI-1 on Non-small cell lung cancer (NSCLC) metastasis and the precise mechanism involved. METHODS The metastatic properties of NSCLC cells were determined by transwell assays… read more here.
Keywords: mir 34a; pai; metastasis; non small ... See more keywords
TRIM59 attenuates IL-1β-driven cartilage matrix degradation in osteoarthritis via direct suppression of NF-κB and JAK2/STAT3 signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.130
Abstract: The tripartite motif (TRIM) protein family are implicated in a wide array of cellular processes, including cell growth, differentiation, apoptosis and inflammation. This study aimed to investigate the specific function of TRIM59 in chondrocytes and… read more here.
Keywords: jak2 stat3; matrix; signaling pathway; trim59 ... See more keywords
Berberinesuppresses bladdercancercell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114575
Abstract: Hyperactivation of signal transducer and activator of transcription 3 (STAT3) is strongly associated with cancer initiation, progression, metastasis, chemoresistance, and immune evasion; thus, STAT3 has beenintenselystudiedasatherapeutictargetfor cancer treatment. Berberine (BBR), an active component extracted from… read more here.
Keywords: upregulation mir; jak1 stat3; stat3; stat3 signaling ... See more keywords
BRM/SMARCA2 promotes the proliferation and chemoresistance of pancreatic cancer cells by targeting JAK2/STAT3 signaling.
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DOI: 10.1016/j.canlet.2017.05.006
Abstract: BACKGROUND BRM is one of two evolutionarily conserved catalytic ATPase subunits of SWI/SNF complexes and plays important role in cell proliferation, linage specification and development, cell adhesion, cytokine responses and DNA repair. BRM is often… read more here.
Keywords: pancreatic cancer; proliferation; cancer; cell ... See more keywords
Maintenance of stemness by miR-589-5p in hepatocellular carcinoma cells promotes chemoresistance via STAT3 signaling.
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DOI: 10.1016/j.canlet.2017.11.031
Abstract: The strength and duration of STAT3 signaling are tightly controlled by multiple negative feedback mechanisms under physical conditions. However, how these serial feedback loops are simultaneously disrupted in cancers, leading to constitutive activation of STAT3… read more here.
Keywords: hepatocellular carcinoma; hcc; chemoresistance; mir 589 ... See more keywords
Allosteric inhibitors of the STAT3 signaling pathway.
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DOI: 10.1016/j.ejmech.2020.112122
Abstract: Over-expression and/or hyperactivation of signal transducer and activator of transcription 3 (STAT3) signaling are found in various human diseases, including cancer, autoimmune disorders, and inflammatory diseases. Therefore, STAT3 represents a highly promising therapeutic target for… read more here.
Keywords: inhibitors stat3; allosteric inhibitors; chemistry; signaling pathway ... See more keywords
Urantide alleviates the symptoms of atherosclerotic rats in vivo and in vitro models through the JAK2/STAT3 signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174037
Abstract: Atherosclerosis is the leading cause of human death, and its occurrence and development are related to the urotensin II (UII) and UII receptor (UT) system and the biological function of vascular smooth muscle cells (VSMCs).… read more here.
Keywords: jak2 stat3; vsmcs; signaling pathway; atherosclerotic rats ... See more keywords
Prognostic significance of SOCS3 and its biological function in colorectal cancer.
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DOI: 10.1016/j.gene.2017.06.013
Abstract: Colorectal cancer (CRC) is a common malignant tumor, in which the inflammatory microenvironment plays an important role. STAT3 signaling pathway is regarded as the "bridge" between inflammation and cancer, and involved in the development of… read more here.
Keywords: socs3; colorectal cancer; signaling pathway; expression ... See more keywords