Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118847
Abstract: Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned… read more here.
Keywords: stat3 sirna; chitosan nanoparticles; thiolated chitosan; cancer ... See more keywords
Functionalized LbL Film for Localized Delivery of STAT3 siRNA and Oxaliplatin Combination to Treat Colon Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c22166
Abstract: The aim of the study was to develop and evaluate the efficacy of a functionalized layer-by-layer (LbL) assembled film entrapped with oxaliplatin (OX) and signal transducer and activator of transcription 3 (STAT3) siRNA in the… read more here.
Keywords: film; colon cancer; lbl film; stat3 sirna ... See more keywords
Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-19463-2
Abstract: Hyperactivity of signal transducer and activity of transcription 3 (STAT3) plays a crucial role in melanoma invasion and metastasis. Gene therapy applying siRNA targeting STAT3 is a potential therapeutic strategy for melanoma. In this article,… read more here.
Keywords: melanoma; via dissolving; stat3 sirna; dissolving microneedles ... See more keywords
Treatment of Colon Cancer by Degradable rrPPC Nano-Conjugates Delivered STAT3 siRNA
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s277845
Abstract: Background Drugs that work based on the mechanism of RNA interference have shown strong potential in cancer gene therapy. Although significant progress has been made in small interfering RNA (siRNA) design and manufacturing, ideal delivery… read more here.
Keywords: rrppc; colon cancer; cancer; stat3 sirna ... See more keywords
Characterization of the Interaction of Polymeric Micelles with siRNA: A Combined Experimental and Molecular Dynamics Study
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DOI: 10.3390/polym14204409
Abstract: The simulation of large molecular systems remains a daunting challenge, which justifies the exploration of novel methodologies to keep computers as an ideal companion tool for everyday laboratory work. Whole micelles, bigger than 20 nm… read more here.
Keywords: sirna combined; characterization interaction; micelles sirna; polymeric micelles ... See more keywords
Effect of RNA Interference Targeting STAT3 Gene Combined with Ultrasonic Irradiation and SonoVue Microbubbles on Proliferation and Apoptosis in Keratinocytes of Psoriatic Lesions
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Medical Journal"
DOI: 10.4103/0366-6999.239297
Abstract: Background: Signal transducer and activator of transcription 3 (STAT3) was strongly expressed and activated in psoriatic keratinocytes (KCs) and correlated with the severity of psoriasis. The study aimed to investigate the effects of STAT3 small… read more here.
Keywords: stat3 sirna; apoptosis; combined ultrasonic; ultrasonic irradiation ... See more keywords