STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence
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DOI: 10.1080/15384101.2016.1259037
Abstract: ABSTRACT Cytokines in the developing tumor microenvironment (TME) can drive transformation and subsequent progression toward metastasis. Elevated levels of the Interleukin-6 (IL-6) family cytokine Oncostatin M (OSM) in the breast TME correlate with aggressive, metastatic… read more here.
Keywords: senescence; stat3; induced senescence; stat3 mediated ... See more keywords
β-Elemene Attenuates Renal Fibrosis in the Unilateral Ureteral Obstruction Model by Inhibition of STAT3 and Smad3 Signaling via Suppressing MyD88 Expression
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105553
Abstract: Renal fibrosis is a chronic pathological process that seriously endangers human health. However, the current therapeutic options for this disease are extremely limited. Previous studies have shown that signaling factors such as JAK2/STAT3, Smad3, and… read more here.
Keywords: renal fibrosis; expression; unilateral ureteral; elemene ... See more keywords