Growth hormone/STAT5 signaling in proopiomelanocortin neurons regulates glucoprivic hyperphagia
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110574
Abstract: Several hypothalamic neuronal populations are directly responsive to growth hormone (GH) and central GH action regulates glucose and energy homeostasis. However, the potential role of GH signaling in proopiomelanocortin (POMC) neurons has not been studied… read more here.
Keywords: glucoprivic hyperphagia; pomc neurons; stat5; growth hormone ... See more keywords
PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers.
Sign Up to like & getrecommendations! Published in 2021 at "Translational oncology"
DOI: 10.1016/j.tranon.2021.101283
Abstract: Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD) constitutively… read more here.
Keywords: flt3 itd; itd aml; stat5; stat5 activated ... See more keywords
Interleukin 9 prevents immune thrombocytopenia in mice via JAK/STAT5 signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111801
Abstract: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by autoimmune-mediated platelet destruction and impaired platelet production, which can lead to an increased risk of bleeding. The clinical management of ITP currently remains a challenge for… read more here.
Keywords: treatment; stat5; immune thrombocytopenia; mice ... See more keywords
Recombinant adiponectin alleviates abortion in mice by regulating Th17/Treg imbalance via p38MAPK-STAT5 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biology of reproduction"
DOI: 10.1093/biolre/ioy251
Abstract: Recurrent spontaneous abortion is associated with abnormal maternal tolerance to the semi-allogenic fetus, wherein the Th17/Treg axis plays a crucial role. Adiponectin (APN) is an adipocytokine that is shown to be a novel negative T-cell… read more here.
Keywords: abortion; th17 treg; stat5; recombinant adiponectin ... See more keywords
The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary and Comparative Oncology"
DOI: 10.1111/vco.12311
Abstract: BACKGROUND Mastocytoma are frequently diagnosed cutaneous neoplasms in dogs. In non-resectable mastocytoma patients, novel targeted drugs are often applied. The transcription factor STAT5 has been implicated in the survival of human neoplastic mast cells (MC).… read more here.
Keywords: stat5; target; canine mastocytoma; jak2 stat5 ... See more keywords
PRL/PRLR Can Promote Insulin Resistance by Activating the JAK2/STAT5 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/1456187
Abstract: Objective Although prolactin (PRL) is known to affect food intake, weight gain, and insulin resistance, its effects on lipid metabolism and underlying mechanisms remain underinvestigated. This study aimed to investigate the effects of PRL and… read more here.
Keywords: prlr; insulin resistance; stat5; group ... See more keywords
Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0195
Abstract: Combining standard cytotoxic chemotherapy with BCR-ABL1 tyrosine kinase inhibitors (TKI) has greatly improved the upfront treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). However, due to the development of drug resistance through… read more here.
Keywords: targeting stat5; kinase; stat5; lymphoblastic leukemia ... See more keywords
Abstract LB-108: A potent and selective small molecule degrader of STAT5 for the treatment of hematological malignancies
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-lb-108
Abstract: STAT5 is a member of the signal transducer and activator of transcription family of proteins and is widely recognized as an oncogenic master regulator of hematological malignancies. To date, therapeutic approaches to attenuate aberrant activity… read more here.
Keywords: potent selective; small molecule; stat5; jpx ... See more keywords
Abstract 3647: Anti-tumor actions of neutrophils are mediated via STAT5 inhibition
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3647
Abstract: The overall patient survival rate drops dramatically when localized prostate cancer (PCa) progresses to bone metastatic prostate cancer (BM-PCa). The treatment for BM-PCa is limited to palliative therapy, and it is currently incurable. Neutrophils are… read more here.
Keywords: via stat5; bone; stat5; pca ... See more keywords
CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response
Sign Up to like & getrecommendations! Published in 2022 at "Cell Transplantation"
DOI: 10.1177/09636897221149444
Abstract: Clinically, xenotransplantation often leads to T-cell-mediated graft rejection. Immunosuppressive agents including polyclonal regulatory T cells (poly-Tregs) promote global immunosuppression, resulting in serious infections and malignancies in patients. Xenoantigen-expanded Tregs (xeno-Tregs) have become a promising immune… read more here.
Keywords: xeno; stat5; cd27 xeno; xeno tregs ... See more keywords
Glucocorticoids Paradoxically Induce Intrinsic Steroid Resistance through a STAT5-Mediated Survival Mechanism in T-Cell Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-119930
Abstract: Upfront resistance to glucocorticoids (GCs) confers a poor prognosis for children with T-cell acute lymphoblastic leukemia (T-ALL). Using primary diagnostic samples from the Children's Oncology Group trial AALL1231, we previously demonstrated that one-third of patient… read more here.
Keywords: dex; il7 induced; stat5; il7 ... See more keywords