PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers.
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DOI: 10.1016/j.tranon.2021.101283
Abstract: Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD) constitutively… read more here.
Keywords: flt3 itd; itd aml; stat5; stat5 activated ... See more keywords