Interleukin 9 prevents immune thrombocytopenia in mice via JAK/STAT5 signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111801
Abstract: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by autoimmune-mediated platelet destruction and impaired platelet production, which can lead to an increased risk of bleeding. The clinical management of ITP currently remains a challenge for… read more here.
Keywords: treatment; stat5; immune thrombocytopenia; mice ... See more keywords
Weighted Gene Coexpression Network Analysis Identified IL2/STAT5 Signaling Pathway as an Important Determinant of Peri-Implantitis
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/4202823
Abstract: Objective Peri-implantitis (PI) is one of the main reasons for dental implant failure. Until now, the etiology and pathogenesis of PI remain unclear. Methods In this study, we used differentially expressed genes (DEGs) analysis and… read more here.
Keywords: signaling pathway; il2 stat5; stat5 signaling; expression ... See more keywords
CSF2-STAT5 Signaling in TAMs Contributes to CSF1R Inhibition Resistance.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2021-155
Abstract: CSF1R inhibition combined with STAT5 blockade normalized TAM phenotype and sustained tumor control. read more here.
Keywords: csf2 stat5; stat5 signaling; signaling tams; inhibition ... See more keywords
Activation of the STAT5 Signaling Pathway by Yiqi Jiedu Formula Induces Regulatory T Cell-Mediated Alleviation of Corneal Immunopathological Damage in Mice With Recurrent Herpes Simplex Keratitis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.790787
Abstract: This study aimed to investigate the effect of Yiqi Jiedu (YQJD) formula on the repair of corneal lesions in mice with recurrent herpes simplex virus keratitis (HSK). Sixty female BALB/c mice were randomly divided into… read more here.
Keywords: signaling pathway; treg cells; stat5 signaling; corneal immunopathological ... See more keywords
AMPK Amplifies IL2–STAT5 Signaling to Maintain Stability of Regulatory T Cells in Aged Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012384
Abstract: AMP-activated protein kinase (AMPK), an important regulator of the aging process, is expressed in various immune cells. However, its role in regulatory T cell (Treg) stability during aging is poorly understood. Here, we addressed the… read more here.
Keywords: il2 stat5; stat5 signaling; ampk; ampk amplifies ... See more keywords
Vitamin A- and D-Deficient Diets Disrupt Intestinal Antimicrobial Peptide Defense Involving Wnt and STAT5 Signaling Pathways in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15020376
Abstract: Vitamin A and D deficiencies are associated with immune modulatory effects and intestinal barrier impairment. However, the underlying mechanisms remain unclear. C57BL/6J mice were fed either a diet lacking in vitamin A (VAd), vitamin D… read more here.
Keywords: intestinal antimicrobial; antimicrobial peptide; stat5 signaling; peptide defense ... See more keywords