Signal transducer and activator of transcription 5a (STAT5a) represses mitochondrial gene expression through direct binding to mitochondrial DNA.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.152
Abstract: Signal transducer and activator of transcription (STAT) proteins are latent cytoplasmic transcription factors essential for cytokine signaling. Our previous study showed that interleukin-3 (IL-3) induced STAT5 translocation to mitochondria and binding to mitochondrial DNA (mtDNA)… read more here.
Keywords: transcription; mitochondrial gene; stat5a; gene expression ... See more keywords
STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation and invasion of hepatocellular carcinoma by targeting to mTORC1
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02273-2
Abstract: Chromodomain Y-like 2 (CDYL2), as a member of CDY family known to be involved in spermatogenesis, has been reported to participate in breast cancer development recently, but its exact biological role in hepatocellular carcinoma (HCC)… read more here.
Keywords: hcc; hepatocellular carcinoma; stat5a; cdyl2 slc7a6 ... See more keywords
Single nucleotide polymorphism in STAT5A could not endorse variation in milk production traits in Indian bovine population.
Sign Up to like & getrecommendations! Published in 2021 at "Acta veterinaria Hungarica"
DOI: 10.1556/004.2021.00046
Abstract: The Signal Transducer and Activator of Transcription 5A (STAT5A) gene involved in activating the transcription of milk protein genes was predicted to be influencing milk production traits. The present study was undertaken to investigate the… read more here.
Keywords: milk; production traits; stat5a; polymorphism ... See more keywords
DBC1, Deleted in Breast Cancer 1, Is a Nuclear STAT5A-Interacting Protein in Adipocytes, but Its Primary Effects on GLUT4 Gene Expression and Lipolysis Are STAT5 Independent
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-1761-p
Abstract: STAT5A (signal transducer and activator of transcription 5A) is a transcription factor that plays a role in adipocyte development and function. Although the role of STAT5A in fat cell development is well characterized, its specific… read more here.
Keywords: dbc1; stat5a; lipolysis; expression ... See more keywords
High activation of STAT5A drives peripheral T-cell lymphoma and leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2019.216986
Abstract: Recurrent gain-of-function mutations in the transcription factors STAT5A and much more in STAT5B were found in hematopoietic malignancies with the highest proportion in mature T- and natural killer-cell neoplasms (peripheral T-cell lymphoma, PTCL). No targeted… read more here.
Keywords: ptcl; stat5a; cell; peripheral cell ... See more keywords