The Fyn-Stat5 cascade is required for Fcγ receptor-mediated mast cell function.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2020.104134
Abstract: Mast cells, well established effectors in allergic disease, can be activated by numerous stimuli. We previously found that the Fyn-Stat5B pathway is critical for FcεRI-stimulated mast cell function. Because IgG receptors employ similar signaling pathways,… read more here.
Keywords: mediated mast; mast; stat5b; mast cell ... See more keywords
Optimization of a high-throughput fluorescence polarization assay for STAT5B DNA binding domain-targeting inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113182
Abstract: Signal transducer and activator of transcription 5B (STAT5B) is constitutively activated in multiple cancers as a result of hyperactivating mutations or dysregulation of upstream effectors. Therapeutic strategies have predominantly targeted the Src homology 2 (SH2)… read more here.
Keywords: stat5b; high throughput; domain; dna binding ... See more keywords
Strategies for over-expression and purification of recombinant full length STAT5B in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2017 at "Protein expression and purification"
DOI: 10.1016/j.pep.2016.08.017
Abstract: STAT5B, a ubiquitious transcription factor, has been implicated in the onset and progression of several cancers. Since the inhibition of STAT activity holds significant therapeutic potential, there is a need to develop high-throughput biophysical screening… read more here.
Keywords: protein; full length; escherichia coli; stat5b ... See more keywords
HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00609-1
Abstract: HIV-1 insertions targeting BACH2 or MLK2 are enriched and persist for decades in hematopoietic cells from patients under combination antiretroviral therapy. However, it is unclear how these insertions provide such selective advantage to infected cell… read more here.
Keywords: bach2; stat5b; regulatory cells; mediated insertional ... See more keywords
Abstract 5223: Epigenetic silencing mediated by non-phosphorylated STAT5B prevents differentiation in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-5223
Abstract: STAT5 proteins are transcription factors involved in the regulation of proliferation, apoptosis and differentiation. Upon ligand-mediated activation, phosphorylated STAT5A (pSTAT5A) and pSTAT5B form homo- or heterodimers, translocate to the nucleus and activate transcription. Recent data… read more here.
Keywords: differentiation; aml cells; stat5b; epigenetic silencing ... See more keywords
STAT5b is a marker of poor prognosis, rather than a therapeutic target in glioblastomas
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5414
Abstract: The copy number and mRNA expression of STAT5b were assessed in samples from the TCGA repository of glioblastomas (GBM). The activation of this transcription factor was analyzed on tissue microarrays comprising 392 WHO 2016 GBM… read more here.
Keywords: therapeutic target; marker; glioblastomas; stat5b ... See more keywords