Modulation of the humoral immune response by constitutively active STAT6 expression in murine B cells
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948313
Abstract: The transcription factor STAT6 regulates gene expression in response to IL‐4 and IL‐13. To further investigate how activated STAT6 modulates B cells development and function in vivo, we characterized mice that express a constitutively active… read more here.
Keywords: cd19cre stat6vt; response; constitutively active; expression ... See more keywords
STAT6 controls the stability and suppressive function of regulatory T cells
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250128
Abstract: Signal transducer and activator of transcription 6 (STAT6) promotes tumorigenesis by decreasing the Forkhead box P3+ (Foxp3+) cell frequency allowing for the infiltration of inflammatory cells during the early stages of colitis‐associated cancer (CAC). In… read more here.
Keywords: regulatory cells; stat6 controls; stability suppressive; stat6 ... See more keywords
STAT6 Reliably Distinguishes Solitary Fibrous Tumors from Myofibromas
Sign Up to like & getrecommendations! Published in 2017 at "Head and Neck Pathology"
DOI: 10.1007/s12105-017-0836-8
Abstract: Solitary fibrous tumors (SFT) and myofibromas (MF) historically have belonged to the same morphologic spectrum and have been lumped together under the nonspecific umbrella term, “hemangiopericytoma” along with other pericytic/myoid tumors. While current evidence shows… read more here.
Keywords: solitary fibrous; reliably distinguishes; pathology; stat6 reliably ... See more keywords
Recirculating Th2 cells induce severe thymic dysfunction via IL-4/STAT6 signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.030
Abstract: Thymic involution happened early in life, but a certain ratio of activated CD4+ T cells will persistently recirculate into the thymus from the periphery and it have been suggested to be able to inhibit the… read more here.
Keywords: th2 cells; recirculating th2; induce severe; cells induce ... See more keywords
The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages
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DOI: 10.1016/j.immuni.2017.12.010
Abstract: Summary The molecular basis of signal‐dependent transcriptional activation has been extensively studied in macrophage polarization, but our understanding remains limited regarding the molecular determinants of repression. Here we show that IL‐4‐activated STAT6 transcription factor is… read more here.
Keywords: repression; transcription factor; macrophage; activation ... See more keywords
Dedicator of Cytokinesis 2 (DOCK2) Silencing Protects Against Cerebral Ischemia/Reperfusion by Modulating Microglia Polarization via the Activation of the STAT6 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2022.03.040
Abstract: Cerebral ischemia/reperfusion is the major pathophysiological process in stroke and could lead to severe and permanent disability. The current study aimed to investigate the effects of dedicator of cytokinesis 2 (DOCK2) on cerebral ischemia/reperfusion-induced cerebral… read more here.
Keywords: stat6; dock2; ischemia reperfusion; polarization ... See more keywords
An exopolysaccharide from Bacillus subtilis alleviates airway inflammatory responses via the NF-κB and STAT6 pathways in asthmatic mice
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20212461
Abstract: Abstract Bacillus subtilis is an intestinal probiotic for immune homeostasis and its exopolysaccharide (EPS) is known to possess anti-inflammatory and antioxidant properties. The underlying mechanisms are not yet fully understood. In the present study, we… read more here.
Keywords: stat6; bacillus subtilis; eps treatment; asthmatic mice ... See more keywords
STAT3 and STAT6 polymorphisms predict the severity of adverse reactions in Chinese NSCLC patients receiving EGFR-TKIs therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemotherapy"
DOI: 10.1080/1120009x.2023.2203610
Abstract: A total of 162 non-small cell lung cancer (NSCLC) patients were divided into discovery (N = 68) and validation (N = 94) groups. Nine Janus kinase/Signal transducer and activator of transcription (JAK/STAT) pathway-related single nucleotide polymorphisms were selected to… read more here.
Keywords: egfr tkis; nsclc patients; stat6; group ... See more keywords
PO-055 STAT6 SIRNA reduces proliferation of and induces apoptosis in the human colon adenocarcinoma cell line HT-29
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.99
Abstract: Introduction The transcription factor STAT6 is strongly expressed in various tumours with highest expression in malignant lymphomas and pancreatic, colorectal, prostate and breast cancers. STAT6 expression in colorectal cancer is associated with an increased malignancy… read more here.
Keywords: colon; human colon; cancer; cell ... See more keywords
IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.157091
Abstract: Keloids are considered the manifestation of a fibroproliferative disease characterized by chronic inflammation that is induced following skin injury. Deciphering the underlying mechanism of keloid formation is essential for improving treatment outcomes. Here, we found… read more here.
Keywords: keloid fibrosis; jak stat6; stat6; downregulation ... See more keywords
Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-020-02621-4
Abstract: Background Thymocyte-expressed, positive selection-associated 1 (Tespa1) is a critical signaling molecule in thymocyte development. This study aimed to investigate the regulatory effect of Tespa1 on mast cells in the pathogenesis of asthma and its relationship… read more here.
Keywords: mast; pathway; tespa1; expression ... See more keywords