Transition state analogue of MTAP extends lifespan of APCMin/+ mice
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-87734-6
Abstract: A mouse model of human Familial Adenomatous Polyposis responds favorably to pharmacological inhibition of 5′-methylthioadenosine phosphorylase (MTAP). Methylthio-DADMe-Immucillin-A (MTDIA) is an orally available, transition state analogue inhibitor of MTAP. 5′-Methylthioadenosine (MTA), the substrate for MTAP,… read more here.
Keywords: mtdia; apcmin mice; mice; state analogue ... See more keywords
The transition to magic bullets - transition state analogue drug design.
Sign Up to like & getrecommendations! Published in 2018 at "MedChemComm"
DOI: 10.1039/c8md00372f
Abstract: In the absence of industry partnerships, most academic groups lack the infrastructure to rationally design and build drugs via methods used in industry. Instead, academia needs to work smarter using mechanism-based design. Working smarter can… read more here.
Keywords: transition; design; drug; state analogue ... See more keywords