Chromatin state dictates drug response.
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.355.6331.1277-p
Abstract: Cancer Therapy Drugs inhibiting the phosphoinositide-(3)-kinase (PI3K) signaling pathway are effective in a subset of breast cancer patients. Tumors become resistant to these drugs, however, and this transition is often accompanied by increased transcription of… read more here.
Keywords: drug; state dictates; estrogen receptor; chromatin state ... See more keywords
Physiological State Dictates the Proteasomal-mediated Purging of Misfolded Protein Fragments.
Sign Up to like & getrecommendations! Published in 2019 at "Protein and peptide letters"
DOI: 10.2174/0929866526666191026111951
Abstract: A pivotal feature that underlies the development of neurodegeneration is the accumulation of protein aggregates. In response, eukaryotic cells have evolved sophisticated quality control mechanisms to identify, repair and/or eliminate the misfolded abnormal proteins. Chaperones… read more here.
Keywords: protein; dictates proteasomal; proteasomal mediated; state dictates ... See more keywords