Altered closed state inactivation gating in Kv4.2 channels results in developmental and epileptic encephalopathies in human patients
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DOI: 10.1002/humu.24396
Abstract: Kv4.2 subunits, encoded by KCND2, serve as the pore‐forming components of voltage‐gated, inactivating ISA K+ channels expressed in the brain. ISA channels inactivate without opening in response to subthreshold excitatory input, temporarily increasing neuronal excitability,… read more here.
Keywords: isa channels; state inactivation; developmental epileptic; inactivation ... See more keywords