The N···H hydrogen bond strength in the transition state at the limiting step determines the reactivity of cephalosporins in the active site of L1 metallo-β-lactamase
Sign Up to like & getrecommendations! Published in 2019 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2019.09.004
Abstract: The combined quantum mechanics/molecular mechanics investigation followed by the detailed electron density analysis for 9 cephalosporin–L1 metallo-β-lactamase complexes revealed correlation between the N···H hydrogen bond strength in the transition state at the limiting step and… read more here.
Keywords: bond strength; state limiting; hydrogen bond; metallo lactamase ... See more keywords