The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons
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DOI: 10.1016/j.immuni.2018.11.017
Abstract: Summary As long‐lived post‐mitotic cells, neurons employ unique strategies to resist pathogen infection while preserving cellular function. Here, using a murine model of Zika virus (ZIKV) infection, we identified an innate immune pathway that restricts… read more here.
Keywords: death; infection; state neurons; metabolic state ... See more keywords