Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.09.22.509032
Abstract: Cell state (phenotypic) plasticity is a carefully regulated feature of adult epithelial cells that enables adaptive responses to injury, inflammation, and other forms of stress. Aberrant expansion of the normally restricted capability for cell state… read more here.
Keywords: cell; state; state plasticity; cell state ... See more keywords
Transient Differentiation-State Plasticity Occurs during Acute Lymphoblastic Leukemia Initiation
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/0008-5472.can-24-1090
Abstract: A method merging multicolor flow cytometry with single-cell whole genome sequencing to couple cell identity with clonal lineages uncovers differentiation-state plasticity in leukemia, reconciling blocked differentiation with phenotypic plasticity in cancer. read more here.
Keywords: differentiation; plasticity; leukemia; state plasticity ... See more keywords