Statin-Associated Myopathy-An Elusive Clinical Problem.
Sign Up to like & getrecommendations! Published in 2018 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2018.3128
Abstract: Muscle disorders resulting from statin therapy, the most common manifestation of statin intolerance, are vexing to both patients and physicians. Statin-associated myopathy may appear as a spectrum of manifestations that include myalgias, myopathy, myositis, myonecrosis,… read more here.
Keywords: medicine; statin associated; statin; associated myopathy ... See more keywords
Curcumin: An effective adjunct in patients with statin‐associated muscle symptoms?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12140
Abstract: In spite of the unequivocal efficacy of statins in reducing primary and secondary cardiovascular events, the use of these drugs in a considerable number of patients is limited because of statin intolerance, mainly statin‐associated muscle… read more here.
Keywords: curcumin effective; muscle; statin associated; associated muscle ... See more keywords
Identification and Management of Statin-Associated Symptoms in Clinical Practice: Extension of a Clinician Survey to 12 Further Countries
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-017-6727-0
Abstract: PurposeStatins are the first-choice pharmacological treatment for patients with hypercholesterolemia and at risk for cardiovascular disease; however, a minority of patients experience statin-associated symptoms (SAS) and are considered to have reduced statin tolerance. The objective… read more here.
Keywords: clinical practice; statin associated; treatment; statin ... See more keywords
Low vitamin D does not predict statin associated muscle symptoms but is associated with transient increases in muscle damage and pain.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2016.11.011
Abstract: BACKGROUND AND AIMS Low vitamin D (VITD) may contribute to statin-associated muscle symptoms (SAMS). We examined the influence of baseline and change in VITD in patients with verified SAMS. METHODS SAMS was verified in 120… read more here.
Keywords: muscle; statin associated; vitd; associated muscle ... See more keywords
Statin-associated myopathy and the quest for biomarkers: can we effectively predict statin-associated muscle symptoms?
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2016.09.001
Abstract: Over the past three decades, statins have become the cornerstone of prevention and treatment of atherosclerotic cardiovascular and metabolic diseases. Albeit generally well tolerated, these drugs can elicit a variety of muscle-associated symptoms that represent… read more here.
Keywords: myopathy quest; muscle; statin associated; associated myopathy ... See more keywords
Statin-associated muscle symptoms-Managing the highly intolerant.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2017.01.006
Abstract: Musculoskeletal symptoms are the most commonly reported adverse effects associated with statin therapy. Yet, certain data indicate that these symptoms often present in populations with underlying musculoskeletal complaints and are not likely statin related. Switching… read more here.
Keywords: muscle; statin associated; associated muscle; highly intolerant ... See more keywords
Association of patient, provider and facility related characteristics with statin associated side effects and statin use: Insight from the veteran's affairs healthcare system.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2021.09.050
Abstract: BACKGROUND Statin associated side effects (SASE) are a leading cause of statin discontinuation. OBJECTIVE We evaluated patient, provider, and facility characteristics associated with SASEs and whether these characteristics impact statin utilization. METHODS Patients with atherosclerotic… read more here.
Keywords: statin use; facility; statin associated; associated side ... See more keywords
Statin-associated muscle symptoms: beware of the nocebo effect
Sign Up to like & getrecommendations! Published in 2017 at "The Lancet"
DOI: 10.1016/s0140-6736(17)31163-7
Abstract: Full Text Tables and Figures References Patient-reported statin intolerance, predominantly due to statin-associated muscle symptoms (SAMS), is a common and difficult-to-manage condition affecting millions of patients worldwide. Different expert panels have proposed various definitions and… read more here.
Keywords: statin intolerance; statin associated; associated muscle; statin ... See more keywords
Effects of Vitamin D Supplementation in Patients with Statin-Associated Muscle Symptoms and Low Vitamin D Levels.
Sign Up to like & getrecommendations! Published in 2022 at "Metabolic syndrome and related disorders"
DOI: 10.1089/met.2021.0127
Abstract: Background: Statin therapy is a cornerstone of cardiovascular disease treatment and prevention. Unfortunately, 7%-29% of statin-treated patients complain of muscular fatigue, cramps, and/or pain (statin-associated muscle symptoms [SAMS]). In recent years, the important role of… read more here.
Keywords: vitamin levels; statin associated; associated muscle; muscle ... See more keywords
Coenzyme Q10 as Treatment for Statin-Associated Muscle Symptoms-A Good Idea, but….
Sign Up to like & getrecommendations! Published in 2018 at "Advances in nutrition"
DOI: 10.1093/advances/nmy010
Abstract: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are extremely well tolerated but are associated with a range of mild-to-moderate statin-associated muscle symptoms (SAMS). Estimates of SAMS incidence vary from read more here.
Keywords: statin associated; treatment; associated muscle; coenzyme ... See more keywords
Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial
Sign Up to like & getrecommendations! Published in 2022 at "Circulation. Genomic and Precision Medicine"
DOI: 10.1161/circgen.121.003503
Abstract: Background: Statin-associated muscle symptoms (SAMS) are the most frequently reported adverse events for statin therapies. Previous studies have reported an association between the p.Val174Ala missense variant in SLCO1B1 and SAMS in simvastatin-treated subjects; however, evidence… read more here.
Keywords: statin associated; odyssey outcomes; associated muscle; association ... See more keywords