Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1557
Abstract: Statins can be associated with myopathy. We have undertaken a genomewide association study (GWAS) to discover and validate genetic risk factors for statin‐induced myopathy in a “real‐world” setting. One hundred thirty‐five patients with statin myopathy… read more here.
Keywords: clinical practice; statin induced; association; genomewide association ... See more keywords
Statin-induced myopathy SLCO1B1 521T > C is associated with prediabetes, high body mass index and normal lipid profile in Emirati population.
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2018.03.014
Abstract: BACKGROUND Statin-induced myopathy has been linked to the C allele of a single nucleotide polymorphism (SNP) (rs4149056) of SLCO1B1 gene. This effect is more significant, but not restricted to simvastatin. Many studies have included European,… read more here.
Keywords: lipid profile; statin induced; induced myopathy; population ... See more keywords
Coenzyme Q10 protects against statin-induced myotoxicity in zebrafish larvae (Danio rerio).
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2017.03.021
Abstract: 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the rate-limiting enzyme of the mevalonic acid pathway and is required for cholesterol biosynthesis and the synthesis of Coenzyme Q10 (CoQ10). Statins inhibit HMGCR, thus inhibiting the downstream products of this… read more here.
Keywords: coenzyme q10; statin induced; danio rerio; coenzyme ... See more keywords
Statin-induced necrotizing autoimmune myopathy (SINAM): case report and review of the literature.
Sign Up to like & getrecommendations! Published in 2022 at "Acta clinica Belgica"
DOI: 10.1080/17843286.2022.2156701
Abstract: Statins are a well-known and highly effective treatment for hypercholesterolemia in order to prevent cardiovascular disease. Occasionally, patients may experience muscle-related events such as myalgia or muscle cramps. Recently, SINAM (statin-induced necrotizing autoimmune myopathy) has… read more here.
Keywords: induced necrotizing; statin induced; autoimmune myopathy; necrotizing autoimmune ... See more keywords
68Ga-FAPI PET/CT in a Patient With Statin-Induced Rhabdomyolysis.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000004418
Abstract: ABSTRACT Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of muscle cell contents into blood circulation. There is ample clinical evidence that it is one of the adverse effects of statins. 68Ga-FAPI… read more here.
Keywords: fapi pet; statin induced; rhabdomyolysis; 68ga fapi ... See more keywords
Anti‐HMGCR autoantibodies in self‐limiting statin‐induced myopathy
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.13025
Abstract: Dear Editor, Since their introduction in the 1990s, statins have become one of the most commonly prescribed medications worldwide. By specifically inhibiting 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMGCR), a key enzyme in the cholesterol synthesis pathway, they… read more here.
Keywords: anti hmgcr; hmgcr; statin induced; autoantibodies self ... See more keywords
Statin‐induced dermatomyositis for the practicing dermatologist: a review of the literature
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Dermatology"
DOI: 10.1111/ijd.14751
Abstract: Statins cause a spectrum of muscle‐related adverse events, including autoimmune myopathies such as dermatomyositis (DM). This review aims to describe the events of statin‐induced DM and amyopathic dermatomyositis (ADM) to increase awareness for practicing dermatologists… read more here.
Keywords: literature; statin; statin induced; induced dermatomyositis ... See more keywords
Pazopanib and Statin-Induced Rhabdomyolysis
Sign Up to like & getrecommendations! Published in 2017 at "Case Reports in Oncology"
DOI: 10.1159/000481659
Abstract: Background: The VEGF inhibitor pazopanib is a widely used first-line therapy for the treatment of advanced renal cell carcinoma. Potential drug-drug interactions and toxicities may be underrecognized. Case Presentation: A 73-year-old woman with metastatic renal… read more here.
Keywords: pazopanib; induced rhabdomyolysis; statin induced; rhabdomyolysis ... See more keywords
Mislabeling of Study Design and Overstatement of Findings in “Rechallenging Statin Therapy in Veterans With Statin-Induced Myopathy Post Vitamin D Replenishment”
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacy Practice"
DOI: 10.1177/0897190017699760
Abstract: Kang et al reviewed the clinic electronic medical records of veteran patients with low vitamin D who were willing to restart statin therapy if their issue of self-reported statin-induced myalgia was addressed through intervention and… read more here.
Keywords: vitamin; statin therapy; study design; statin induced ... See more keywords
Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "Acta medica portuguesa"
DOI: 10.20344/amp.16181
Abstract: Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies. Although the… read more here.
Keywords: hmgcr antibodies; induced necrotizing; anti hmgcr; hmgcr ... See more keywords
Activation of Transposable Elements in Human Skeletal Muscle Fibers upon Statin Treatment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010244
Abstract: High cholesterol levels have been linked to a high risk of cardiovascular diseases, and preventative pharmacological care to lower cholesterol levels is critically important. Statins, which are hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are drugs used… read more here.
Keywords: transposable elements; muscle; statin; statin induced ... See more keywords