Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of Bempedoic acid on cardiovascular events in patients with statin intolerance.
Sign Up to like & getrecommendations! Published in 2020 at "American heart journal"
DOI: 10.1016/j.ahj.2020.10.060
Abstract: BACKGROUND Although statins play a pivotal role in the prevention of atherosclerotic cardiovascular disease, many patients fail to achieve recommended lipid levels due to statin-associated muscle symptoms. Bempedoic acid is an oral pro-drug that is… read more here.
Keywords: statin intolerance; clear outcomes; trial; bempedoic acid ... See more keywords
Does Googling lead to statin intolerance?
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2018.02.085
Abstract: BACKGROUND The nocebo effect, where patients with expectations of adverse effects are more likely to experience them, may contribute to the high rate of statin intolerance found in observational studies. Information that patients read on… read more here.
Keywords: statin intolerance; statin side; number websites; websites statin ... See more keywords
Clinical and economic consequences of statin intolerance in the United States: Results from an integrated health system.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2016.10.003
Abstract: BACKGROUND Although statins are considered safe and effective, they have been associated with statin intolerance (SI) in clinical and observational studies. OBJECTIVE The objective of this study was to describe the clinical and economic consequences… read more here.
Keywords: statin intolerance; risk; integrated health; clinical economic ... See more keywords
Statin-associated muscle symptoms: beware of the nocebo effect
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DOI: 10.1016/s0140-6736(17)31163-7
Abstract: Full Text Tables and Figures References Patient-reported statin intolerance, predominantly due to statin-associated muscle symptoms (SAMS), is a common and difficult-to-manage condition affecting millions of patients worldwide. Different expert panels have proposed various definitions and… read more here.
Keywords: statin intolerance; statin associated; associated muscle; statin ... See more keywords
PSYCHOSOCIAL FACTORS AND STATIN INTOLERANCE: DATA FROM THE REASONS FOR GEOGRAPHIC AND RACIAL DIFFERENCES IN STROKE (REGARDS) STUDY
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)35088-x
Abstract: Background: Previous studies have shown that medication intolerance may be affected by adverse events to medication and psychosocial factors. We investigated associations between quality of life, low self-rated health, stress and statin intolerance in a… read more here.
Keywords: statin intolerance; data reasons; factors statin; intolerance ... See more keywords
Prevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa
Sign Up to like & getrecommendations! Published in 2021 at "Xenobiotica"
DOI: 10.1080/00498254.2021.1945165
Abstract: Abstract Statins, the standard treatment for hypercholesterolaemia, among the most widely prescribed, have been associated with side effects, including statin intolerance. The aim of this study was to determine the background prevalence of SLCO1B1 SNVs… read more here.
Keywords: hypercholesterolaemia; statin intolerance; prevalence; prevalence slco1b1 ... See more keywords
Prevalence of statin intolerance: a meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac015
Abstract: AIMS Statin intolerance (SI) represents a significant public health problem for which precise estimates of prevalence are needed. Statin intolerance remains an important clinical challenge, and it is associated with an increased risk of cardiovascular… read more here.
Keywords: risk; analysis; overall prevalence; statin intolerance ... See more keywords
P705Step by step diagnosis and management of statin intolerance: position paper from an international lipid expert panel
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz747.0310
Abstract: Statin intolerance is a clinical syndrome whereby adverse effects associated with statin therapy (most commonly muscle symptoms) result in the discontinuation of therapy. Statin discontinuation is associated with increased risk of adverse cardiac outcomes. Many… read more here.
Keywords: statin intolerance; diagnosis; step; statin ... See more keywords
Statin intolerance: new data and further options for treatment
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Cardiology"
DOI: 10.1097/hco.0000000000000874
Abstract: Purpose of review Hypercholesterolemia is a major risk factor for cardiovascular diseases. Administration of statins represents the cornerstone of the prevention and treatment of cardiovascular disease, with demonstrated long-term safety and efficacy. This review aims… read more here.
Keywords: treatment; new data; statin intolerance; options treatment ... See more keywords
Tolerance of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) Inhibitors in Patients With Self-Reported Statin Intolerance
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacy Practice"
DOI: 10.1177/0897190018799218
Abstract: Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been shown to lower atherogenic lipid markers in patients with statin intolerance; however, external validity of these findings is unclear in patients with self-reported statin intolerance.… read more here.
Keywords: statin intolerance; pcsk9 inhibitors; intolerance; reported statin ... See more keywords
Role of Anti-PCSK9 Antibodies in the Treatment of Patients with Statin Intolerance.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170616111647
Abstract: Statin intolerance is usually defined as the inability of a patient to tolerate statintreatment due to muscle-related complaints. While randomised trials show that these complaints occure with similar frequency in patients receiving placebo, namely in… read more here.
Keywords: statin intolerance; pcsk9 antibodies; ldl; role anti ... See more keywords