Comparison of pleiotropic effects of statins vs fibrates on laboratory parameters in patients with dyslipidemia
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DOI: 10.1097/md.0000000000023427
Abstract: Abstract Differences in the mechanism of action and potential pleiotropic effects between statins and fibrates would potentially drive a different effect on various laboratory parameters, but this remains controversial because of a paucity of reports… read more here.
Keywords: statin users; statins fibrates; fibrate users; matched pairs ... See more keywords
Data Mining of the FDA Adverse Event Reporting System and Animal Experiments for Assessment of Rhabdomyolysis Risk Associated with Lipid-lowering Drugs
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DOI: 10.7150/ijms.109034
Abstract: Despite extensive research on pharmacokinetic interactions between hydroxymethylglutaryl-CoA reductase inhibitors (statins) and fibrates, the underlying pharmacodynamic mechanisms contributing to the increased risk of rhabdomyolysis remain unclear. This study aimed to determine the differences among statins… read more here.
Keywords: data mining; fda adverse; risk; statins fibrates ... See more keywords