Bioactive staurosporine derivatives from the Streptomyces sp. NB-A13.
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DOI: 10.1016/j.bioorg.2018.09.016
Abstract: Six new (1-6) and nine known (7-15) staurosporine derivatives were isolated from the rice solid fermentation of the marine-derived Streptomyces sp. NB-A13. The structures of the new staurosporine derivatives were established by extensive spectroscopic data… read more here.
Keywords: staurosporine; derivatives streptomyces; bioactive staurosporine; streptomyces a13 ... See more keywords
Streptomyces sp. BV410: Interspecies cross‐talk for staurosporine production
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.15726
Abstract: Sequencing and genome analysis of two co‐isolated streptomycetes, named BV410‐1 and BV410‐10, and the effect of their co‐cultivation on the staurosporine production. read more here.
Keywords: staurosporine; streptomyces bv410; bv410 interspecies; interspecies cross ... See more keywords
Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A
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DOI: 10.1128/msphere.00056-17
Abstract: The impact of fungal pathogens on human health is devastating. One of the most pervasive fungal pathogens is Candida albicans, which kills ~40% of people suffering from bloodstream infections. Treatment of these infections is extremely… read more here.
Keywords: staurosporine; fungal pathogens; filamentation; candida albicans ... See more keywords
Cytotoxic Indolocarbazoles From a Marine-Derived Streptomyces Sp. OUCMDZ-5380
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DOI: 10.3389/fmicb.2022.957473
Abstract: Under the guidance of global natural product social molecular networking, three new indolocarbazoles named streptocarbazoles F–H (1-3), along with staurosporine (4) were isolated from the marine-derived Streptomyces sp. OUCMDZ-5380. Structures of streptocarbazoles F–H were, respectively,… read more here.
Keywords: staurosporine; oucmdz 5380; streptomyces oucmdz; marine derived ... See more keywords
Staurosporine alleviates cisplatin chemoresistance in human cancer cell models by suppressing the induction of SQSTM1/p62.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology reports"
DOI: 10.3892/or.2018.6615
Abstract: Cancer is one of the leading causes of mortality worldwide. Platinum‑based chemotherapeutic agents such as cisplatin are the first line of treatment for many types of cancers. However, the development of cisplatin resistance after prolonged… read more here.
Keywords: staurosporine; treatment; p62; cisplatin ... See more keywords