Hypoxia Microenvironment Preconditioning Attenuated Myocardial Ischemia‐Reperfusion Injury via Stc1‐Mediating Cardiomyocyte Self‐Protection and Neutrophil Polarization
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DOI: 10.1002/advs.202411880
Abstract: Ischemic preconditioning (IPC) therapy application to attenuate myocardial ischemia‐reperfusion (MI/R) injury in clinical practice remains challenging. The secretome, derived from hypoxia‐preconditioned cardiomyocytes (SHPC), potentially mimics the IPC microenvironment and facilitates IPC clinical translation. This study… read more here.
Keywords: neutrophil polarization; microenvironment; hypoxia; injury ... See more keywords
The Regulatory Effect of MicroRNA-101-3p on Disc Degeneration by the STC1/VEGF/MAPK Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/1073458
Abstract: Aims. Accumulating evidence reported that the microRNA (miRNA) took an important role in intervertebral disc degeneration (IDD). In this study, we revealed a novel miRNA regulatory mechanism in IDD. Main Methods. The miRNA microarray analyses… read more here.
Keywords: stc1; mir 101; vegf mapk; mapk pathway ... See more keywords
Metabolic and Epigenetic Regulation of SMAD7 by Stanniocalcin-1 (STC1) Ameliorates Lung Fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0445oc
Abstract: As shown in our previous studies, the intratracheal-administration of stanniocalcin-1 (STC1) ameliorates pulmonary fibrosis by reducing oxidative and endoplasmic reticulum stress through the uncoupling of respiration in a bleomycin (BLM)-treated mouse model. However, the overall… read more here.
Keywords: stc1 ameliorates; smad7; stc1; stanniocalcin stc1 ... See more keywords
Molecular and Clinical Significance of Stanniocalcin-1 Expression in Breast Cancer Through Promotion of Homologous Recombination-Mediated DNA Damage Repair
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.731086
Abstract: Stanniocalcin-1 (STC1) is a glycoprotein hormone whose abnormal expression has been reported to be associated with a variety of tumors, but its function in breast cancer is not well understood. Through modulation of STC1 expression… read more here.
Keywords: stc1; breast; homologous recombination; breast cancer ... See more keywords