Metabolic improvement after gastric bypass correlates with changes in IGF-regulatory proteins stanniocalcin-2 and IGFBP-4.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2021.154886
Abstract: BACKGROUND Pregnancy-associated plasma protein-A (PAPP-A) is an enzyme that increases IGF-activity through cleavage of IGF-binding proteins (IGFBPs), primarily IGFBP-4, whereby bound IGF-I becomes released as a free molecule. The enzymatic activity of PAPP-A is irreversibly… read more here.
Keywords: igfbp; gastric bypass; papp; changes igf ... See more keywords
Light-driven Oxidative Demethylation Reaction Catalyzed by a Rieske-type Non-heme Iron Enzyme Stc2.
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DOI: 10.1021/acscatal.2c04232
Abstract: Rieske-type non-heme iron oxygenases/oxidases catalyze a wide range of transformations. Their applications in bioremediation or biocatalysis face two key barriers: the need of expensive NAD(P)H as a reductant and a proper reductase to mediate the… read more here.
Keywords: rieske type; type non; reaction; stc2 ... See more keywords
The significance of Stanniocalcin 2 in malignancies and mechanisms.
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DOI: 10.1080/21655979.2021.1977551
Abstract: Human stanniocalcin 2 (STC2) is an ortholog of fish stanniocalcins (STCs) and is widely expressed in various organs and tissues. The gene is localized on chromosome 5q33 or 5q35. STC2 has been implicated in glucose… read more here.
Keywords: stanniocalcin; stanniocalcin malignancies; malignancies mechanisms; stc2 ... See more keywords
The proliferation and angiogenesis in hemangioma-derived endothelial cells is affected by STC2 medicated VEGFR2/Akt/eNOS pathway
Sign Up to like & getrecommendations! Published in 2023 at "Pakistan Journal of Medical Sciences"
DOI: 10.12669/pjms.39.4.7384
Abstract: Objective: Stanniocalcin-2 (STC2), a secreted glycoprotein that is involved in the regulation of angiogenesis, was proposed as one of the mechanisms of neovascularization in hemangioma (HA). We aimed to investigate the effect of STC2 on… read more here.
Keywords: endothelial cells; stc2; angiogenesis; proliferation angiogenesis ... See more keywords
Gene expression analyses identify a relationship between stanniocalcin 2 and the malignant behavior of colorectal cancer
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DOI: 10.2147/ott.s167780
Abstract: Background Colorectal cancer (CRC) is one of the main causes of cancer-related death worldwide. Stanniocalcin 2 (STC2), a secreted glycoprotein, has been suggested to exert various functions in progression of many cancers. However, the precise… read more here.
Keywords: colorectal cancer; gene expression; cancer; stc2 ... See more keywords
Sp1 contributes to overexpression of stanniocalcin 2 through regulation of promoter activity in colon adenocarcinoma
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DOI: 10.3748/wjg.v25.i22.2776
Abstract: BACKGROUND Aberrant expression of stanniocalcin 2 (STC2) is implicated in colon adenocarcinoma (COAD). A previous study identified that STC2 functions as a tumor promoter to drive development of some cancers, but the role of its… read more here.
Keywords: overexpression; promoter; stc2; coad ... See more keywords