Protein engineering: Regulatory perspectives of stearoyl CoA desaturase.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.03.171
Abstract: Stearoyl Co A desaturase (SCD) is a rate-limiting lipogenic enzyme that plays an integral role in catalyzing the synthesis of monounsaturated fatty acids, chiefly oleate and palmitoleate. Both contribute a major part of the biological… read more here.
Keywords: desaturase; stearoyl coa; protein engineering; scd ... See more keywords
A functional variant in the stearoyl-CoA desaturase (SCD) gene promoter affects gene expression in ovine muscle
Sign Up to like & getrecommendations! Published in 2019 at "Livestock Science"
DOI: 10.1016/j.livsci.2018.11.015
Abstract: Abstract The nutritional quality of lambs may be improved with increased stearoyl-CoA desaturase (SCD) gene expression, which increases the desaturation of stearic acid to oleic acid. The aim of this study was to evaluate the… read more here.
Keywords: stearoyl coa; scd gene; muscle; gene ... See more keywords
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.11.028
Abstract: In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each other. Lipidomic profiling of human αS-expressing yeast revealed increases in… read more here.
Keywords: lipidomic analysis; parkinson; stearoyl coa; neurotoxicity ... See more keywords
Bovine Stearoyl-CoA Desaturase 1 Promotes Adipogenesis by Activating the PPARγ Receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c05147
Abstract: Stearoyl-CoA desaturase 1 (SCD1) is a rate-limiting enzyme that mainly catalyzes the saturated fatty acids (SFAs) into the monounsaturated fatty acids (MUFAs). The expression level of SCD1 is positively correlated with the marbling score. However,… read more here.
Keywords: ppar receptor; stearoyl coa; bovine; coa desaturase ... See more keywords
Stearoyl-CoA desaturase 1 regulates malignant progression of cervical cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2079253
Abstract: ABSTRACT The primary regulatory gene for fatty acid synthesis, stearoyl-CoA desaturase 1 (SCD1), has been linked to the progression of several malignancies. Its role in cervical cancer remains unclear till now. This paper aimed to… read more here.
Keywords: cervical cancer; cancer; progression; stearoyl coa ... See more keywords
Cis- and Trans-variations of Stearoyl-CoA Desaturase Provide New Insights into the Mechanisms of Diverged Pattern of Phenotypic Plasticity for Temperature Adaptation in Two Congeneric Oyster Species
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad015
Abstract: Abstract The evolution of phenotypic plasticity plays an essential role in adaptive responses to climate change; however, its regulatory mechanisms in marine organisms which exhibit high phenotypic plasticity still remain poorly understood. The temperature-responsive trait… read more here.
Keywords: gigas; plasticity; stearoyl coa; coa desaturase ... See more keywords
Targeting stearoyl-CoA desaturase in solid tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-4044
Abstract: Cancer cells are demarcated from normal cells by distinct biological hallmarks, including the reprogramming of metabolic processes. One of the key players involved in metabolic reprogramming is stearoyl-CoA desaturase (SCD), which converts saturated fatty acids… read more here.
Keywords: coa desaturase; cancer; stearoyl coa; solid tumors ... See more keywords
A hint from zebrafish models of hepatic tumorigenesis: Targeting stearoyl-CoA desaturase
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.26645
Abstract: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death and is one of major regional diseases in China [1]. Given the decades of advancement in surgery, targeted drug, and immunotherapy, the overall survival… read more here.
Keywords: tumorigenesis; stearoyl coa; fatty acids; hepatic tumorigenesis ... See more keywords
The single nucleotide polymorphism g.133A>C in the stearoyl CoA desaturase gene (SCD) promoter affects gene expression and quali-quantitative properties of river buffalo milk.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dairy science"
DOI: 10.3168/jds.2018-15059
Abstract: The stearoyl-CoA desaturase (SCD) gene has been investigated in depth in ruminants because of its effect on milk fat composition. In river buffalo, the single nucleotide polymorphism (SNP) g.133A>C in the gene promoter has been… read more here.
Keywords: milk; river buffalo; stearoyl coa; genotype ... See more keywords
Sequential Dynamics of Stearoyl-CoA Desaturase-1(SCD1)/Ligand Binding and Unbinding Mechanism: A Computational Study
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11101435
Abstract: Stearoyl-CoA desaturase-1 (SCD1 or delta-9 desaturase, D9D) is a key metabolic protein that modulates cellular inflammation and stress, but overactivity of SCD1 is associated with diseases, including cancer and metabolic syndrome. This transmembrane endoplasmic reticulum… read more here.
Keywords: desaturase scd1; stearoyl coa; sequential dynamics; scd1 ... See more keywords
Stearoyl CoA Desaturase-1 Silencing in Glioblastoma Cells: Phospholipid Remodeling and Cytotoxicity Enhanced upon Autophagy Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113014
Abstract: Modulation of lipid metabolism is a well-established cancer hallmark, and SCD1 has been recognized as a key enzyme in promoting cancer cell growth, including in glioblastoma (GBM), the deadliest brain tumor and a paradigm of… read more here.
Keywords: inhibition; glioblastoma; increase; stearoyl coa ... See more keywords