Safety and Dosing Study of a Cholecystokinin Receptor Antagonist in Non‐alcoholic Steatohepatitis
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2745
Abstract: High saturated fat diets have been shown to raise blood levels of cholecystokinin (CCK) and induce nonalcoholic steatohepatitis (NASH). CCK receptors are expressed on stellate cells and are responsible for hepatic fibrosis when activated. The… read more here.
Keywords: safety; receptor antagonist; steatohepatitis; fibrosis ... See more keywords
The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis
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DOI: 10.1002/hep.28971
Abstract: Tripartite motif 8 (TRIM8), an E3 ligase ubiquitously expressed in various cells, is closely involved in innate immunity. However, its role in nonalcoholic steatohepatitis is largely unknown. Here, we report evidence that TRIM8 is a… read more here.
Keywords: trim8; tripartite motif; steatohepatitis; insulin resistance ... See more keywords
Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29724
Abstract: Nonalcoholic fatty liver disease (NAFLD) and its progressive form non‐alcoholic steatohepatitis (NASH), are rapidly becoming among the top causes of cirrhosis, hepatocellular carcinoma, and indications for liver transplantation. Other than lifestyle modification through diet and… read more here.
Keywords: fatty liver; steatohepatitis; nonalcoholic fatty; liver disease ... See more keywords
Of Mice and Men and Nonalcoholic Steatohepatitis
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30186
Abstract: Mouse models of non-alcoholic fatty liver disease (NAFLD) are required to both elucidate the pathogenesis of the disease and also to assess therapeutic interventions. The first criterion for a useful model is that it reproduces… read more here.
Keywords: fibrosis; histopathology; disease; men nonalcoholic ... See more keywords
γδ T Cells Promote Steatohepatitis by Orchestrating Innate and Adaptive Immune Programming
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DOI: 10.1002/hep.30952
Abstract: The recruitment and activation of inflammatory cells in the liver delineates the transition from hepatic steatosis to steatohepatitis (SH). read more here.
Keywords: promote steatohepatitis; cells promote; orchestrating innate; steatohepatitis ... See more keywords
TRIM31 confers protection against nonalcoholic steatohepatitis by deactivating MAP3K7.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32526
Abstract: BACKGROUND AND AIMS As a global health threat, nonalcoholic steatohepatitis (NASH) has been confirmed to be a chronic progressive liver disease that is strongly associated with obesity. However, no approved drugs or efficient therapeutic strategies… read more here.
Keywords: nonalcoholic steatohepatitis; trim31 confers; protection nonalcoholic; confers protection ... See more keywords
Inhibition of mPGES-2 ameliorates non-alcoholic steatohepatitis by activating NR1D1 via heme.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32671
Abstract: BACKGROUND & AIMS Non-alcoholic fatty liver disease (NAFLD), a complex metabolic syndrome, has limited therapeutic options. Microsomal prostaglandin E synthase-2 (mPGES-2) was originally discovered as a prostaglandin E2 (PGE2 ) synthase; however, it does not… read more here.
Keywords: inhibition mpges; non alcoholic; mpges ameliorates; role mpges ... See more keywords
IL‐17A‐mediated ERK1/2/p65 signaling pathway is associated with cell apoptosis after non‐alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.1960
Abstract: Interleukin (IL)‐17A is pro‐inflammatory cytokine which has been identified as a noninvasive marker of the pathogenesis of non‐alcoholic steatohepatitis (NASH). However, the underlying role of IL‐17A in NASH progression remains unclear. This study was designed… read more here.
Keywords: apoptosis; erk1 p65; signaling pathway; mediated erk1 ... See more keywords
Mouse Model of Alcoholic Steatohepatitis.
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DOI: 10.1007/978-1-0716-0704-6_15
Abstract: Alcoholic liver disease (ALD) is one of the most common causes of chronic liver disease in Western countries. The spectrum of ALD ranges from simple steatosis to steatohepatitis to cirrhosis and hepatocellular carcinoma. Over the… read more here.
Keywords: alcoholic steatohepatitis; model; steatohepatitis; binge ... See more keywords
Long noncoding RNA lncARSR promotes hepatic lipogenesis via Akt/SREBP-1c pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.127
Abstract: Non-alcoholic fatty liver disease and steatohepatitis (NAFLD and NASH) account for the majority of liver disease in industrialized countries. However, the pathogenesis still unclear. Long non-coding RNAs (lncRNAs) has been reported to be involved in… read more here.
Keywords: long noncoding; lipogenesis; lncarsr; steatohepatitis ... See more keywords
Estrogen receptor α mediated M1/M2 macrophages polarization plays a critical role in NASH of female mice.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.01.085
Abstract: Owing to lacking protective effect of estrogen, OVX mice have higher risk of non-alcoholic fatty liver disease compared with normal female mice, when fed with high fat diet. Our study was to explore how estrogen… read more here.
Keywords: mice; female mice; role; estrogen ... See more keywords