Rab11 plays a key role in stellate cell differentiation via non-canonical Notch pathway in Malpighian tubules of Drosophila melanogaster.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental biology"
DOI: 10.1016/j.ydbio.2020.01.002
Abstract: Rab11, a member of Rab-GTPase family, and a marker of recycling endosomes have been reported to be involved in the differentiation of various tissues in Drosophila. Here we report a novel role of Rab11 in… read more here.
Keywords: rab11; non canonical; stellate; canonical notch ... See more keywords
SPOCK1 overexpression induced by platelet-derived growth factor-BB promotes hepatic stellate cell activation and liver fibrosis through the integrin α5β1/PI3K/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Laboratory Investigation"
DOI: 10.1038/s41374-020-0425-4
Abstract: Sparc/osteonectin, cwcv, and kazal-like domain proteoglycan 1 (SPOCK1) is a matricellular protein which regulates cell proliferation, invasion, and survival but the function of SPOCK1 in liver fibrosis is obscure. In this study, we found that… read more here.
Keywords: liver fibrosis; pi3k akt; signaling pathway; spock1 ... See more keywords
Hyperthermia-induced stellate cell deactivation to enhance dual chemo and pH-responsive photothermal therapy for pancreatic cancers.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr04235e
Abstract: For pancreatic ductal adenocarcinoma (PDAC) treatment, the deactivation of pancreatic stellate cells (PSCs) by blocking the transforming growth factor β (TGF-β) pathway is a promising strategy to inhibit stroma, enhance drug penetration, and greatly amplify… read more here.
Keywords: deactivation; responsive photothermal; photothermal therapy; therapy ... See more keywords
1α,25(OH) 2 D 3 Regulates the TGF-β1/Samd Signaling Pathway Inhibition of Hepatic Stellate Cell Activation
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DOI: 10.1055/a-2463-5530
Abstract: Abstract Objective To investigate the effect of 1α,25(OH) 2 D 3 on hepatic stellate cells and the mechanism of the TGF-β1/Smad signaling pathway. Methods LX2 cells were treated with TGF-β1 and different concentrations of 1α,25(OH)… read more here.
Keywords: stellate; cell activation; stellate cell; hepatic stellate ... See more keywords
Nuclear Galectin-1 promotes KRAS-dependent activation of pancreatic cancer stellate cells
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2424051122
Abstract: Significance Our findings provide insights into the biology of pancreatic stellate cell (PSC) activation in pancreatic ductal adenocarcinoma (PDAC), a leading cause of cancer mortality. By identifying a nuclear role for Galectin-1 (Gal1) in regulating… read more here.
Keywords: cancer; stellate; activation; nuclear galectin ... See more keywords
Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activity
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Medicine"
DOI: 10.1080/07853890.2022.2164047
Abstract: Abstract The sympathetic nervous system and the immune system are responsible for producing neurotransmitters and cytokines that interact by binding to receptors; due to this, there is communication between these systems. Liver immune cells and… read more here.
Keywords: liver cirrhosis; nervous system; stellate; hepatic stellate ... See more keywords
Melatonin protects against lipid‐induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice
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DOI: 10.1111/jpi.12404
Abstract: Lipid generates reactive oxygen species (ROS) in consequence to mitochondrial fission followed by inflammation in propagating hepatic fibrosis. The interaction of SIRT1/Mitofusin2 is critical for maintaining mitochondrial integrity and functioning, which is disrupted upon excess… read more here.
Keywords: cell; hepatic fibrosis; activation; melatonin ... See more keywords
Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.adf6696
Abstract: Organ size is maintained by the controlled proliferation of distinct cell populations. In the mouse liver, hepatocytes in the midlobular zone that are positive for cyclin D1 (CCND1) repopulate the parenchyma at a constant rate… read more here.
Keywords: stellate cells; stellate; hepatic stellate; liver homeostasis ... See more keywords
A Transcriptional Sequencing Analysis of Islet Stellate Cell and Pancreatic Stellate Cell
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Diabetes Research"
DOI: 10.1155/2018/7361684
Abstract: Background Our previous studies have shown that islet stellate cell (ISC), similar to pancreatic stellate cell (PSC) in phenotype and biological characters, may be responsible for the islet fibrosis in type 2 diabetes. To further… read more here.
Keywords: stellate cell; pancreatic stellate; islet stellate; analysis ... See more keywords
Activated Hepatic Stellate Cells Promote the M1 to M2 Macrophage Transformation and Liver Fibrosis by Elevating the Histone Acetylation Level
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/9883831
Abstract: Liver fibrosis results from the formation of fibrous scars of hepatic stellate cells by various chronic liver diseases. Considering that the liver is the most important metabolic organ in the human body, exploring the metabolic… read more here.
Keywords: stellate cells; liver fibrosis; stellate; hepatic stellate ... See more keywords
Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.158288
Abstract: Pancreatic fibrosis is a complication of chronic pancreatitis and is a prominent feature of pancreatic cancer. Pancreatic fibrosis is commonly observed in patients with prolonged pancreatic duct obstruction, which elevates intrapancreatic pressure. We show here… read more here.
Keywords: pressure; stellate; mice; fibrosis ... See more keywords