A Deactivation Factor of Fibrogenic Hepatic Stellate Cells Induces Regression of Liver Fibrosis in Mice
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DOI: 10.1002/hep.30965
Abstract: Hepatic stellate cells (HSCs), a key player in the progression of liver fibrosis, are activated by various inflammatory stimuli and converted to myofibroblast‐like cells with excessive collagen production. Despite many attempts to suppress activation of… read more here.
Keywords: fibrosis; liver fibrosis; deactivation; hepatic stellate ... See more keywords
Perivenous Stellate Cells Are the Main Source of Myofibroblasts and Cancer‐Associated Fibroblasts Formed After Chronic Liver Injuries
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DOI: 10.1002/hep.31848
Abstract: Studies of the identity and pathophysiology of fibrogenic HSCs have been hampered by a lack of genetic tools that permit specific and inducible fate‐mapping of these cells in vivo. Here, by single‐cell RNA sequencing of… read more here.
Keywords: perivenous stellate; source myofibroblasts; myofibroblasts cancer; cells main ... See more keywords
Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma
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DOI: 10.1002/ijc.32899
Abstract: Hepatocellular carcinoma (HCC) is the most common type of primary tumor in the liver and is a leading cause of cancer‐related death worldwide. Activated hepatic stellate cells (HSCs) are key components of the HCC microenvironment… read more here.
Keywords: hepatocellular carcinoma; hscs; activated hscs; hepatic stellate ... See more keywords
Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl‐2 in hepatic stellate cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23097
Abstract: Hepatic fibrosis is an important early stage in the evolution of liver cirrhosis, and specific medicine and therapeutic measures are unavailable to date. Hepatic stellate cells (HSCs) are the main cells involved in the formation… read more here.
Keywords: stellate cells; hepatic fibrosis; hepatic stellate; fibrosis ... See more keywords
Myrrhone inhibits the progression of hepatic fibrosis by regulating the abnormal activation of hepatic stellate cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23177
Abstract: We focus on exploring the antihepatic fibrosis effect of Myrrhone (Myr), a compound extracted from myrrh, and its effective target. Mouse hepatic stellate cells (HSCs) were cultured in vitro and activated by transforming growth factor‐β… read more here.
Keywords: stellate cells; hepatic fibrosis; myr; hepatic stellate ... See more keywords
Fasting inhibits hepatic stellate cells activation and potentiates anti‐cancer activity of Sorafenib in hepatocellular cancer cells
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DOI: 10.1002/jcp.25987
Abstract: Hepatocellular carcinoma (HCC) has a poor outcome. Most HCCs develop in the context of liver fibrosis and cirrhosis caused by chronic inflammation. Short‐term fasting approaches enhance the activity of chemotherapy in preclinical cancer models, other… read more here.
Keywords: hcc; activity; activation; cancer ... See more keywords
Apoptotic and antihepatofibrotic effect of honokiol via activation of GSK3β and suppression of Wnt/β‐catenin pathway in hepatic stellate cells
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DOI: 10.1002/ptr.6824
Abstract: Though honokiol, derived from the Magnolia tree, was known to suppress renal fibrosis, pulmonary fibrosis, non‐alcoholic steatoheptitis, inflammation and cancers, the underlying antifibrotic mechanisms of honokiol are not fully understood in hepatic stellate cells until… read more here.
Keywords: catenin; hepatic stellate; honokiol; gsk3 ... See more keywords
Cytokine Profiling and Orthotopic Xenografing of Pancreatic Stellate Cells.
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DOI: 10.1007/978-1-4939-8879-2_14
Abstract: Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the most lethal human malignancies with a poor prognosis due to systemic metastasis and a high recurrence rate. Interactions between tumor and stromal cells play a… read more here.
Keywords: pancreatic stellate; profiling orthotopic; cytokine profiling; xenografing pancreatic ... See more keywords
Schistosoma japonicum soluble egg antigen inhibits TNF-α-induced IL-34 expression in hepatic stellate cells
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DOI: 10.1007/s00436-018-6165-3
Abstract: Hepatic fibrosis is characterized by the activation of the main collagen-producing cells of the liver, hepatic stellate cells, and is associated with inflammation. Although the involvement of numerous inflammatory cytokines has been reported, IL-34 in… read more here.
Keywords: induced expression; tnf induced; hepatic stellate; stellate cells ... See more keywords
Aldolase C is a novel molecular marker for folliculo-stellate cells in rodent pituitary
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DOI: 10.1007/s00441-020-03200-1
Abstract: The anterior pituitary gland is composed of five types of hormone-producing cells and folliculo-stellate cells. Folliculo-stellate cells do not produce anterior pituitary hormones but they are thought to play important roles as stem cells, phagocytes,… read more here.
Keywords: aldolase; folliculo stellate; marker; anterior pituitary ... See more keywords
ASPP2 Inhibits the Profibrotic Effects of Transforming Growth Factor-β1 in Hepatic Stellate Cells by Reducing Autophagy
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DOI: 10.1007/s10620-017-4816-3
Abstract: BackgroundApoptosis-stimulating protein of p53-2 (ASPP2) is a damage-inducible P53-binding protein that enhances damage-induced apoptosis. Fibrosis is a wound-healing response, and hepatic stellate cells (HSCs) are key players in liver fibrogenesis. However, little is known about… read more here.
Keywords: fibrosis; tgf; hepatic stellate; aspp2 ... See more keywords