Malformin C preferentially kills glioblastoma stem‐like cells via concerted induction of proteotoxic stress and autophagic flux blockade
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13756
Abstract: Glioblastoma is a highly aggressive brain tumor for which there is no cure. The dire prognosis of this disease is largely attributable to a high level of heterogeneity, including the presence of a subpopulation of… read more here.
Keywords: malformin preferentially; like cells; malformin; autophagic flux ... See more keywords
Wireless Manipulation of Magnetic/Piezoelectric Micromotors for Precise Neural Stem‐Like Cell Stimulation
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201910108
Abstract: Precise neural electrical stimulation, which is a means of promoting neuronal regeneration, is a promising solution for patients with neurotrauma and neurodegenerative diseases. In this study, wirelessly controllable targeted motion and precise stimulation at the… read more here.
Keywords: stem like; neural stem; cell; precise neural ... See more keywords
Knockdown of STAT3 targets a subpopulation of invasive melanoma stem‐like cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11134
Abstract: Transcription factor signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many cancers, including melanomas. Active, phosphorylated STAT3 contributes to tumor growth and formation of the immunosuppressive tumor microenvironment. Recent evidence suggests… read more here.
Keywords: melanoma; melanoma cscs; like cells; stat3 ... See more keywords
Dual‐specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem‐like cell phenotype in human endometrial cancer
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.32965
Abstract: The prognosis of patients with high‐grade or advanced‐stage endometrial cancer remains poor. As cancer stem‐like cells (CSCs) are thought to be associated with endometrial cancers, it is essential to investigate the molecular mechanisms that regulate… read more here.
Keywords: cancer stem; dual specificity; stem like; endometrial cancer ... See more keywords
Frizzled 6 endows high‐grade serous ovarian cancer with stem‐like properties and chemoresistance
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23789
Abstract: Stem‐like properties contribute to tumor growth, metastasis, and chemoresistance. High‐grade serous ovarian cancer (HGSOC) exhibits a very aggressive phenotype characterized by extensive metastasis, rapid progression, and therapy resistance. Frizzled 6 (FZD6) is overexpressed in HGSOC,… read more here.
Keywords: stem like; high grade; grade serous; like properties ... See more keywords
A replicating stem‐like cell that contributes to bone morphogenetic protein 2‐induced heterotopic bone formation
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.20-0378
Abstract: Bone morphogenetic protein 2 (BMP2)‐induced heterotopic bone formation (HBF) starts synchronously from zero upon BMP2 induction, which is advantageous for lineage tracking. The studies reported here in GLAST‐CreErt2:tdTomato red (TR)floxSTOPflox mice during BMP2‐induced HBF show… read more here.
Keywords: like cell; heterotopic bone; bone; stem like ... See more keywords
Enrichment of Melanoma Stem-Like Cells via Sphere Assays.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1205-7_14
Abstract: Sphere assays are widely used in vitro techniques to enrich and evaluate the stem-like cell behavior of both normal and cancer cells. Utilizing three-dimensional in vitro sphere culture conditions provide a better representation of tumor… read more here.
Keywords: like cells; stem like; enrichment melanoma; sphere assays ... See more keywords
In Vitro Methods for the Study of Glioblastoma Stem-Like Cell Radiosensitivity.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1225-5_3
Abstract: Ionizing radiation is a critical component of glioblastoma (GBM) therapy. Recent data have implicated glioblastoma stem-like cells (GSCs) as determinants of GBM development, maintenance, and treatment response. Understanding the response of GSCs to radiation should… read more here.
Keywords: radiosensitivity; methods study; vitro methods; stem like ... See more keywords
Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2797-z
Abstract: PurposeGlioblastoma is still intractable despite the progress in therapies, and the intractability is attributable to a minor population of stem-like tumor cells. As a niche harboring quiescent stem-like tumor cells with potentially high tumorigenicity, we… read more here.
Keywords: glioblastoma; like tumor; tumor cells; stem like ... See more keywords
Exosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1/Akt Axis
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Neurobiology"
DOI: 10.1007/s12035-024-04002-0
Abstract: Exosomes play a crucial role in regulating crosstalk between tumor and tumor stem-like cells through their cargo molecules. Circular RNAs (circRNAs) have recently been demonstrated to be critical factors in tumorigenesis. This study focuses on… read more here.
Keywords: tumorigenicity; circznf800; like cells; stem like ... See more keywords
Nanoquinacrine sensitizes 5-FU-resistant cervical cancer stem-like cells by down-regulating Nectin-4 via ADAM-17 mediated NOTCH deregulation
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Oncology"
DOI: 10.1007/s13402-018-0417-1
Abstract: PurposeCervical cancer is a major cause of cancer-related death in women world-wide. Although the anti-metabolite 5-FU is widely used for its treatment, its clinical utility is limited due to the frequent occurrence of drug resistance… read more here.
Keywords: cancer stem; like cells; metastatic cells; stem like ... See more keywords