Deciphering the Heterogeneity Landscape of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles for Precise Selection in Translational Medicine.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202453
Abstract: Owing to the low immunogenicity and high target affinities, mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) have been considered promising therapeutics for disease treatments. However, MSC-EVs that are harvested from different tissues present unique biological features… read more here.
Keywords: msc evs; heterogeneity; medicine; stem stromal ... See more keywords
Recent advances in mesenchymal stem/stromal cells (MSCs)‐based approaches for osteoarthritis (OA) therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biology International"
DOI: 10.1002/cbin.12008
Abstract: Recently, mesenchymal stem/stromal cells (MSCs) transplantation has been introduced as a promising option to support cartilage structure and improve its function in preclinical models and patients suffering from osteoarthritis (OA). MSCs strongly provoke their preferred… read more here.
Keywords: mscs based; mesenchymal stem; cells mscs; stem stromal ... See more keywords
Human Skeletal Muscle-Derived Mesenchymal Stem/Stromal Cell Isolation and Growth Kinetics Analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2018_201
Abstract: The most studied sources of mesenchymal stem/stromal cells (MSCs) are bone marrow and adipose tissue. However skeletal muscle represents an interesting source of diverse subpopulations of MSCs, such as paired box 7 (Pax-7)-positive satellite cells,… read more here.
Keywords: skeletal muscle; muscle; stem stromal; muscle derived ... See more keywords
Decellularized Adipose Tissue Scaffolds for Soft Tissue Regeneration and Adipose-Derived Stem/Stromal Cell Delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7799-4_6
Abstract: Surgically discarded adipose tissue is not only an abundant source of multipotent adipose-derived stem/stromal cells (ASCs) but can also be decellularized to obtain a biomimetic microenvironment for tissue engineering applications. The decellularization methods involve processing… read more here.
Keywords: stem stromal; decellularized adipose; tissue; derived stem ... See more keywords
Epigenetic Regulators of Mesenchymal Stem/Stromal Cell Lineage Determination
Sign Up to like & getrecommendations! Published in 2020 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-020-00616-0
Abstract: Although many signalling pathways have been discovered to be essential in mesenchymal stem/stromal (MSC) differentiation, it has become increasingly clear in recent years that epigenetic regulation of gene transcription is a vital component of lineage… read more here.
Keywords: lineage; stem stromal; lineage determination; mesenchymal stem ... See more keywords
Conditioning of myoblast secretome using mesenchymal stem/stromal cell spheroids improves bone repair.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.05.018
Abstract: Local muscle loss associated with open fractures remains an obstacle to functional recovery and bone healing. Muscle cells secrete bioactive myokines that elicit autocrine and paracrine effects and initiate signaling pathways for regenerating damaged muscle… read more here.
Keywords: conditioned media; muscle; stem stromal; bone ... See more keywords
Genetically modified mesenchymal stem/stromal cells transfected with adiponectin gene can stably secrete adiponectin
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.06.007
Abstract: Aims: Mesenchymal stem/stromal cells (MSCs) hold promises for the treatment of diverse diseases and regeneration of injured tissues. Genetic modification of MSCs through gene delivery might enhance their therapeutic potential. Adiponectin has been appeared as… read more here.
Keywords: adiponectin gene; stem stromal; adiponectin; mscs ... See more keywords
Toxicity Impacts on Human Adipose Mesenchymal Stem/Stromal Cells Acutely Exposed to Aroclor and Non-Aroclor Mixtures of Polychlorinated Biphenyl
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.2c07281
Abstract: Polychlorinated biphenyl (PCB) accumulates in adipose where it may impact the growth and function of cells within the tissue. This is particularly concerning during adolescence when adipocytes expand rapidly. Herein, we sought to understand how… read more here.
Keywords: polychlorinated biphenyl; adipose mesenchymal; human adipose; mesenchymal stem ... See more keywords
Prospectively isolated mesenchymal stem/stromal cells are enriched in the CD73+ population and exhibit efficacy after transplantation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05099-1
Abstract: Mesenchymal stem/stromal cells (MSCs), which reside in the bone marrow (BM) and various other tissues, can self-renew and differentiate into mesenchymal lineages. Many groups have harvested rat MSCs (rMSCs) from rat BM (rBM) by using… read more here.
Keywords: stem stromal; exhibit; stromal cells; prospectively isolated ... See more keywords
Reduced aldehyde dehydrogenase expression in preeclamptic decidual mesenchymal stem/stromal cells is restored by aldehyde dehydrogenase agonists
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42397
Abstract: High resistance to oxidative stress is a common feature of mesenchymal stem/stromal cells (MSC) and is associated with higher cell survival and ability to respond to oxidative damage. Aldehyde dehydrogenase (ALDH) activity is a candidate… read more here.
Keywords: dehydrogenase; stem stromal; expression; aldehyde dehydrogenase ... See more keywords
Chondrogenic preconditioning of mesenchymal stem/stromal cells within a magnetic scaffold for osteochondral repair
Sign Up to like & getrecommendations! Published in 2022 at "Biofabrication"
DOI: 10.1088/1758-5090/ac5935
Abstract: Stem cell therapy using mesenchymal stem/stromal cells (MSCs) represents a novel approach to treating severe diseases, including osteoarthritis. However, the therapeutic benefit of MSCs is highly dependent on their differentiation state, which can be regulated… read more here.
Keywords: topography; mesenchymal stem; stem stromal; magnetic scaffolds ... See more keywords