LncRNA UCA1 is necessary for TGF‐β‐induced epithelial–mesenchymal transition and stemness via acting as a ceRNA for Slug in glioma cells
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DOI: 10.1002/2211-5463.12533
Abstract: The 5‐year survival rate of patients with glioma is < 5%, and therefore there is an urgent need to find novel potential targets for facilitating its diagnosis and treatment. The long non‐coding RNA (lncRNA) UCA1… read more here.
Keywords: stemness; glioma; lncrna uca1; slug ... See more keywords
SLC34A2 promotes neuroblastoma cell stemness via enhancement of miR‐25/Gsk3β‐mediated activation of Wnt/β‐catenin signaling
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DOI: 10.1002/2211-5463.12594
Abstract: Cancer stem cells contribute to cancer progression, but the mechanisms underlying neuroblastoma stem cell development are unclear. Here, we examined the roles of the transcription factor SLC34A2 in regulating the stemness of neuroblastoma cells. We… read more here.
Keywords: stemness; mir gsk3; neuroblastoma cell; neuroblastoma cells ... See more keywords
Programming Niche Accessibility and In Vitro Stemness with Intercellular DNA Reactions.
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DOI: 10.1002/adma.201804861
Abstract: Stem cells generally exist in low abundance and tend to lose stemness in the absence of self-renewal signals. While extracellular-matrix-mimicking techniques have been developed to support stem cell proliferation, the lack of niche cells in… read more here.
Keywords: intercellular dna; stemness; niche; stem ... See more keywords
SALL4 ‐ KHDRBS3 network enhances stemness by modulating CD44 splicing in basal‐like breast cancer
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DOI: 10.1002/cam4.1296
Abstract: Understanding the mechanism by which cancer cells enhance stemness facilitates cancer therapies. Here, we revealed that a stem cell transcription factor, SALL4, functions to enhance stemness in basal‐like breast cancer cells. We used shRNA‐mediated knockdown… read more here.
Keywords: stemness; like breast; breast cancer; cancer ... See more keywords
Investigate the stemness of adult adipose‐derived stromal cells based on single‐cell RNA‐sequencing
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DOI: 10.1002/cbin.11898
Abstract: The cellular heterogeneity and genetic features of stemness of adipose‐derived stromal cells (ADSCs) remain unclear. Using single‐cell RNA sequencing (scRNA‐seq), we investigated the genomic features of the stemness gene in ADSCs with genetic variability. We… read more here.
Keywords: cell; derived stromal; stemness; adipose derived ... See more keywords
FAT1 modulates EMT and stemness genes expression in hypoxic glioblastoma
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DOI: 10.1002/ijc.31092
Abstract: Glioblastoma (GBM) is characterized by the presence of hypoxia, stemness and local invasiveness. We have earlier demonstrated that FAT1 promotes invasiveness, inflammation and upregulates HIF‐1α expression and its signaling in hypoxic GBM. Here, we have… read more here.
Keywords: stemness; emt stemness; fat1; expression ... See more keywords
The miRNA‐149‐5p/MyD88 axis is responsible for ursolic acid‐mediated attenuation of the stemness and chemoresistance of non‐small cell lung cancer cells
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DOI: 10.1002/tox.22891
Abstract: Although the inhibitory roles of ursolic acid (UA) have been established in various tumors, its effects on the stemness of non‐small cell lung cancer (NSCLC) cells are still unclear. Here, we constructed NSCLC cells with… read more here.
Keywords: 149 myd88; stemness; a549 cells; myd88 axis ... See more keywords
Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes
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DOI: 10.1002/tox.23057
Abstract: Colorectal cancer stem cell (CSC) has been regarded to be the root of colorectal cancer progression. However, there is still no effective therapeutic method targeting colorectal CSC in clinical application. Here, we investigated the effects… read more here.
Keywords: csc; stemness; colorectal cancer; ferroptosis ... See more keywords
MiR‐1246 is responsible for lung cancer cells‐derived exosomes‐mediated promoting effects on lung cancer stemness via targeting TRIM17
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DOI: 10.1002/tox.23625
Abstract: The stemness of lung cancer cells contributes to drug resistance, tumor occurrence, progression, and recurrence; however, the underlying mechanisms are still fragmentary. In the present study, it was found that exosomes from cisplatin‐resistant cells and… read more here.
Keywords: lung cancer; cancer; stemness; cancer cells ... See more keywords
PRMT5 determines the sensitivity to chemotherapeutics by governing stemness in breast cancer
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DOI: 10.1007/s10549-017-4597-6
Abstract: PurposeAcquired resistance to chemotherapeutic agents in breast cancer is a major clinical challenge. Recent studies have shown that the emergence of cancer stem cells contributes to the development of drug resistance, and the protein arginine… read more here.
Keywords: stemness; breast cancer; prmt5; resistance ... See more keywords
Overview of Cancer Stem Cells and Stemness for Community Oncologists
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DOI: 10.1007/s11523-017-0508-3
Abstract: Advances in cancer research in the past have led to an evolving understanding of cancer pathogenesis and the development of novel drugs that significantly improve patient outcomes. However, many patients still encounter treatment resistance, recurrence,… read more here.
Keywords: stemness; cancer stem; treatment; cancer ... See more keywords