Preserving LXR by inhibiting T39: A step closer to treating atherosclerosis and steatohepatitis?
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28946
Abstract: zumab, Secukinumab, and Brodalumab) are being evaluated for treatments of psoriasis, psoriatic arthritis, rheumatoid arthritis, and ankylosing spondylitis. The current study by Gomes and coworkers adds interesting insights into the cellular and molecular mechanisms underlying… read more here.
Keywords: t39 step; closer treating; lxr inhibiting; inhibiting t39 ... See more keywords
One Step Closer to a Milestone in Climate Modeling
Sign Up to like & getrecommendations! Published in 2019 at "Eos"
DOI: 10.1029/2019eo129065
Abstract: A pair of revisions to the Energy Exascale Earth System Model improves its ability to capture late afternoon and nocturnal rainfall as well as the timing and movement of convection. read more here.
Keywords: closer milestone; one step; climate modeling; step closer ... See more keywords
Oral-gut connection: one step closer to an integrated view of the gastrointestinal tract?
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal Immunology"
DOI: 10.1038/mi.2017.116
Abstract: Although an enrichment of orally derived bacteria is reported in the gut microbiota of patients with several diseases, it is mostly unknown whether oral bacteria can colonize and induce intestinal inflammation. In a recent paper… read more here.
Keywords: closer integrated; connection one; one step; oral gut ... See more keywords
One step closer to ultra-long-acting PREP?
Sign Up to like & getrecommendations! Published in 2019 at "AIDS"
DOI: 10.1097/qad.0000000000002118
Abstract: Pre-exposure prophylaxis (PrEP) has become an increasingly popular means of preventing HIV transmission, but the only currently approved form requires users to take a daily pill. Long-acting forms of PrEP could offer a simpler regimen,… read more here.
Keywords: ultra long; prep; long acting; closer ultra ... See more keywords
One step closer to myocardial physiology: From PV loop analysis to state‐of‐the‐art myocardial imaging
Sign Up to like & getrecommendations! Published in 2022 at "Acta Physiologica"
DOI: 10.1111/apha.13759
Abstract: Recent advances in cardiac imaging have revitalized the assessment of fundamental physiological concepts. In the field of cardiac physiology, invasive measurements with pressure‐volume (PV) loops have served as the gold standard methodology for the characterization… read more here.
Keywords: loop; myocardial physiology; one step; physiology ... See more keywords
One step closer to cancer nanomedicine
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.add3666
Abstract: Description High-throughput tool uncovers links between cell signaling and nanomaterial uptake The promise of chemotherapeutic nanomedicine has tantalized clinicians and patients for decades. Nanoparticles (NPs) can directly target tumor cells, which would reduce the amount… read more here.
Keywords: cancer nanomedicine; cell; one step; chemistry ... See more keywords
Reslizumab and Eosinophilic Asthma: One Step Closer to Precision Medicine?
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00242
Abstract: Human eosinophils represent approximately 1% of peripheral blood leukocytes. However, these cells have the propensity to leave the blood stream and migrate into inflamed tissues. Eosinophilic inflammation is present in a significant proportion of patients… read more here.
Keywords: medicine; patients severe; eosinophilic asthma; one step ... See more keywords