Step-Economical Mechanosynthesis of Hybrid Azoles: Deciphering their π-Orbital and Pharmacological Characteristics.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300008
Abstract: A hybrid pharmacophore approach for unifying 1,2,3-triazole with 1,2,4-triazole cores to prepare mixed triazoles were accomplished by ball-milling condition. The developed chemistry works under the catalysis of cupric oxide nanoparticles with salient features like one-jar… read more here.
Keywords: mechanosynthesis hybrid; hybrid azoles; economical mechanosynthesis; deciphering orbital ... See more keywords
Atom and step economical synthesis of acyclic quaternary centers via iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes
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DOI: 10.1039/d2sc02790a
Abstract: Quaternary benzylic centers are accessed with high atom and step economy by Ir-catalyzed alkene hydroarylation. These studies provide unique examples of the use of non-polarized 1,1-disubstituted alkenes in branch selective Murai-type hydro(hetero)arylations. Detailed mechanistic studies… read more here.
Keywords: atom step; step; economical synthesis; synthesis acyclic ... See more keywords
An Efficient and Step-economical Synthesis of β-Carboline Tethered Imidazopyrido[3,4-b]indoles from Acetals
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DOI: 10.1039/d4nj01467g
Abstract: An efficient one-pot pseudo three component cascade annulation reaction has been devised to generate the fluorescent β-carboline tethered imidazopyrido[3,4-b]indole derivatives. These scaffolds were afforded in high yields via one-pot cascade... read more here.
Keywords: tethered imidazopyrido; efficient step; step economical; economical synthesis ... See more keywords