Experimental factors that impact CaV1.2 channel pharmacology—Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the “step-step-ramp” voltage protocol
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DOI: 10.1371/journal.pone.0276995
Abstract: Background and purpose CaV1.2 channels contribute to action potential upstroke in pacemaker cells, plateau potential in working myocytes, and initiate excitation-contraction coupling. Understanding drug action on CaV1.2 channels may inform potential impact on cardiac function.… read more here.
Keywords: step ramp; pharmacology; temperature; experimental factors ... See more keywords